AUP1

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AUP1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases AUP1, ancient ubiquitous protein 1
External IDs MGI: 107789 HomoloGene: 7239 GeneCards: AUP1
RNA expression pattern
PBB GE AUP1 220525 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181575

NM_001025446
NM_001301649
NM_007517

RefSeq (protein)

NP_853553

n/a

Location (UCSC) Chr 2: 74.53 – 74.53 Mb Chr 6: 83.05 – 83.06 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene.[3][4][5]

Function[edit]

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.[5]

Interactions[edit]

AUP1 has been shown to interact with ITGA2B.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Jang W, Weber JS, Bashir R, Bushby K, Meisler MH (Jan 1997). "Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13". Genomics. 36 (2): 366–8. doi:10.1006/geno.1996.0477. PMID 8812468. 
  4. ^ a b Kato A, Kawamata N, Tamayose K, Egashira M, Miura R, Fujimura T, Murayama K, Oshimi K (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J Biol Chem. 277 (32): 28934–41. doi:10.1074/jbc.M204340200. PMID 12042322. 
  5. ^ a b "Entrez Gene: AUP1 ancient ubiquitous protein 1". 

External links[edit]

Further reading[edit]