From Wikipedia, the free encyclopedia
Jump to: navigation, search
Alpha-2-glycoprotein 1, zinc-binding
Protein AZGP1 PDB 1t7v.png
PDB rendering based on 1t7v.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols AZGP1 ; ZA2G; ZAG
External IDs OMIM194460 MGI103163 HomoloGene915 GeneCards: AZGP1 Gene
RNA expression pattern
PBB GE AZGP1 209309 at tn.png
PBB GE AZGP1 217014 s at tn.png
More reference expression data
Species Human Mouse
Entrez 563 12007
Ensembl ENSG00000160862 ENSMUSG00000037053
UniProt P25311 Q64726
RefSeq (mRNA) NM_001185 NM_013478
RefSeq (protein) NP_001176 NP_038506
Location (UCSC) Chr 7:
99.97 – 99.98 Mb
Chr 5:
137.98 – 137.99 Mb
PubMed search [1] [2]

Zinc-alpha-2-glycoprotein is a protein that in humans is encoded by the AZGP1 gene.[1][2]

This gene expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lung epithelium.[3] In 2009, it was found that smoking increases expression of this gene, which is why smoking cessation leads to weight gain.[3] Zinc-alpha-2-glycoprotein levels also rise with onset of Diabetes 2, which accounts for weight loss thereafter.


  1. ^ Ueyama H, Niwa M, Tada T, Sasaki M, Ohkubo I (Jul 1991). "Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene". Biochem Biophys Res Commun 177 (2): 696–703. doi:10.1016/0006-291X(91)91844-3. PMID 2049092. 
  2. ^ "Entrez Gene: AZGP1 alpha-2-glycoprotein 1, zinc-binding". 
  3. ^ a b Vanni, H; Kazeros, A; Wang, R; Harvey, BG; Ferris, B; De, BP; Carolan, BJ; Hübner, RH; et al. (2009). "Cigarette Smoking Induces Overexpression of a Fat-Depleting Gene AZGP1 in the Human". Chest 135 (5): 1197–208. doi:10.1378/chest.08-1024. PMC 2679098. PMID 19188554. 

Further reading[edit]