AZIN1

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AZIN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAZIN1, AZI, AZIA1, OAZI, OAZIN, ODC1L, antizyme inhibitor 1, AZI1
External IDsMGI: 1859169 HomoloGene: 22933 GeneCards: AZIN1
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for AZIN1
Genomic location for AZIN1
Band8q22.3Start102,826,357 bp[1]
End102,893,864 bp[1]
RNA expression pattern
PBB GE AZIN1 212461 at fs.png

PBB GE AZIN1 201772 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001102458
NM_001301688
NM_018745

RefSeq (protein)

NP_001095928
NP_001288617
NP_061215

Location (UCSC)Chr 8: 102.83 – 102.89 MbChr 15: 38.49 – 38.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Antizyme inhibitor 1 is a protein that in humans is encoded by the AZIN1 gene.[5][6][7]

Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155096 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037458 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Koguchi K, Kobayashi S, Hayashi T, Matsufuji S, Murakami Y, Hayashi S (Nov 1997). "Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor". Biochim Biophys Acta. 1353 (3): 209–16. doi:10.1016/s0167-4781(97)00106-1. PMID 9349715.
  6. ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  7. ^ a b "Entrez Gene: AZIN1 antizyme inhibitor 1".

External links[edit]

Further reading[edit]