Along with the rest of the Mad Men cast, Staton won a Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Drama Series in 2008 and 2009. He has made appearances in TV series such as Law & Order: SVU, 7th Heaven and Without a Trace. He performed extensive voice and facial acting for the video game L.A. Noire, in which he plays the protagonist, Cole Phelps.
Staton is married to actress Connie Fletcher. They have three sons. Their first, Beckett was born on June 29, 2010 and their second, Connor on June 21, 2012. Their third, Grady was born on February 16, 2015.