Abafungin

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Abafungin
Structural formula of abafungin
Space-filling model of the abafungin molecule
Clinical data
Trade names Abasol
Routes of
administration
Topical (cream)
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ECHA InfoCard 100.125.129
Chemical and physical data
Formula C21H22N4OS
Molar mass 378.491 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Abafungin (INN) is a broad-spectrum antifungal agent with a novel mechanism of action for the treatment of dermatomycoses.

Abasol is a topical cream formulation of abafungin by York Pharma.[1]

Mechanism of action[edit]

Unlike imidazole- and triazole-class antifungals, abafungin directly impairs the fungal cell membrane.[2]

In addition, abafungin inhibits the enzyme sterol 24-C-methyltransferase, modifying the composition of the fungal membrane.[3]

Abafungin has antibiotic activity against gram-positive bacteria as well as sporicidal activity.[4]

References[edit]

  1. ^ York Pharma: Regulatory Update – Abasol Archived September 27, 2007, at the Wayback Machine.
  2. ^ Borelli C1, Schaller M, Niewerth M, Nocker K, Baasner B, Berg D, Tiemann R, Tietjen K, Fugmann B, Lang-Fugmann S, Korting HC. "Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi". Chemotherapy. 2008;54(4):245-59
  3. ^ Borelli C1, Schaller M, Niewerth M, Nocker K, Baasner B, Berg D, Tiemann R, Tietjen K, Fugmann B, Lang-Fugmann S, Korting HC. "Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi". Chemotherapy. 2008;54(4):245-59
  4. ^ Ginter-Hanselmayer, Gabriele (March 2009), Arbeitsunterlagen zur 42. wissenschaftlichen Fortbildungsveranstaltung für Apothekerinnen und Apotheker: Infektionskrankheiten, Österreichische Apothekerkammer, p. 103