|Other names||BA058, BIM-44058|
|Chemical and physical data|
|Molar mass||3959.649 g·mol−1|
|3D model (JSmol)|
Abaloparatide (brand name Tymlos) is a parathyroid hormone-related protein (PTHrP) analog drug used to treat osteoporosis. Like the related drug teriparatide, and unlike bisphosphonates, it is an anabolic (i.e., bone growing) agent.
In 2017, it was approved to treat postmenopausal osteoporosis in the United States.
Abaloparatide is indicated to treat postmenopausal women with osteoporosis who are at high risk of bone fractures.
The dose recommended is 80mcg subcutaneous injection once a day, administered in the periumbilical area using a prefilled pen device containing 30 doses.
The most common side effects reported by more than 2% of clinical trials subjects are hypercalciuria, dizziness, nausea, headache, palpitations, fatigue, upper abdominal pain and vertigo.
Preclinical studies revealed that abaloparatide systemic daily administration leads to a dose- and time-dependent increase in the incidence of osteosarcoma in rodents. However, whether abaloparatide-SC will cause osteosarcoma in humans is unknown. Thus, the use of abaloparatide is not recommended for individuals at increased risk of osteosarcoma. Additionally, its use is not advised for more than 2 years during a patient's lifetime.
Abaloparatide is 34 amino acid synthetic analog of PTHrP. It has 41% homology to parathyroid hormone (PTH) (1-34) and 76% homology to parathyroid hormone-related protein (PTHrP) (1-34). It works as an anabolic agent for the bone, through selective activation of the parathyroid hormone 1 receptor (PTH1R), a G protein-coupled receptor (GPCR) expressed in the osteoblasts and osteocytes. Abaloparatide preferentially binds the RG conformational state of the PTH1R, which in turn elicits a transient downstream cyclic AMP signaling response towards to a more anabolic signaling pathway.
Abaloropatide was known as BIM-44058 when it was first discovered at Ipsen and as BA058 while under development. The anabolic effects of abaloparatide on bone were demonstrated in two preclinical studies conducted in ovariectomized rats. Both studies showed increased cortical and trabecular bone volume and density, and trabecular microarchitecture improvement in vertebral and nonvertebral bones after short-term and long-term daily subcutaneous injection of abaloparatide compared to controls. Recent studies indicated a dose-dependent increased in bone mass and strength in long-term abalorapatide treatment. However, it was also found that prolonged abalorapatide-SC treatment leads to increased incidence of osteosarcoma. To date, there is no evidence for increased risk of bone tumors due to prolonged systemic administration in humans. Based on preclinical data, the FDA does not advised the use of abaloparatide-SC for more than 2 years, or in patients with history of Paget disease and/or other conditions that exacerbates the risk of developing osteosarcoma.
Phase II trials were initiated in 2008. A 24-week randomized trial was conducted in postmenopausal women with osteoporosis (n=222) assessing bone mass density (BMD) changes as the primary endpoint. Significant BMD increase at doses of 40 and 80 mcg were found in the lumbar spine, femur and hips of abaloparatide-treated participants compared to placebo. Additionally, abaloparatide showed superior anabolic effects on the hips compared to teriparatide.
In the phase III (2011-2014) Abaloparatide Comparator Trial in Vertebral Endpoints (ACTIVE) trial, an 18-months randomized, multicenter, double-blinded, placebo-controlled study evaluated the long-term efficacy of abaloparatide compared to placebo and teriparatide in 2,463 postmenopausal women (± 69 years old). Women who received daily injections of abaloparatide experienced substantial reduction in the incidence of fractures compared to placebo. Additionally, greater BMD increase at 6, 12 and 18 months in spinal, hips and femoral bones was observed in abaloparatide compared to placebo and teriparatide-treated subjects.
Participants who completed 18 months of abaloparatide or placebo in the ACTIVE study were invited to participate in an extended open-labeled study - ACTIVExtend study (2012-2016). Subjects (n=1139) received additional 2 years of 70 mg of alendronate, Vitamin D (400 to 800 IU), and calcium (500–1000 mg) supplementation daily. Combined abaloparatide and alendronate therapy reduced significantly the incidence of vertebral and nonvertebral fractures.
A clinical trial assessing the effectiveness of abaloparatide in altering spinal bone mineral density (BMD) in male subjects is expected to start in the first quarter of 2018. If successful, Radius Health aims to submit a sNDA to expand the use of abaloparatide-SC to treat men with osteoporosis.
Abaloparatide-SC is manufactured by Radius Health, Inc. (Nasdaq: RDUS), a biomedical company based in Waltham, Massachusetts. The firm reported that sales for abaloparatide were $3.5 million for the third quarter of 2017. The company announced a net loss of $57.8 million, or $1.31 per share for the third quarter of 2017, compared to $19.2 million for the same quarter of 2016. The net loss most likely reflects the substantial expenses associated with the preparation and launching of abaloparatide into the US market in May 2017.
In July 2017, Radius Health licensed rights to Teijin Limited for abaloparatide-SC manufacture and commercialization in Japan. Teijin is developing abaloparatide-SC under agreement with Ipsen Pharma S.A.S., and is conducting a phase III clinical trial in Japanese patients with osteoporosis.
Radius Health filed a Marketing Authorization Application (MAA) in November 2015, which was validated in December, 2015, and still under regulatory assessment by the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA). As in July 2017, the CHMP issued a second Day-180 List of Outstanding Issues, which Radius is addressing with the CHMP.
In February 2016 a NDA was filed to the FDA, Radius NDA for abaloparatide-SC was accepted in May, 2016. A Prescription Drug User Fee Act (PDUFA) date was initially granted on March 30, 2016, but then extended to June 30, 2017. As previously stated, abaloparatide injection was approved for use in postmenopausal osteoporosis on April 28, 2017.
Radius Health currently holds three patents on abaloparatide-SC, with expiration dates from 2027-2028. The patents relate to the drug composition (US 8148333), and the drug delivery methods (US 7803770 B2 and US 8748382-B2).
Teijin was granted use of Radius Health's intellectual property in July 2017, for the development, manufacture and commercialization of abaloparatide-sc in Japan.
- H. Spreitzer (18 January 2016). "Neue Wirkstoffe – Abaloparatid". Österreichische Apothekerzeitung (in German) (2/2016): 12.
- "Drugs@FDA: FDA Approved Drug Products". www.accessdata.fda.gov. Retrieved 2017-11-03.
- Jolette, Jacquelin; Attalla, Bassem; Varela, Aurore; Long, Gerald G.; Mellal, Nacera; Trimm, Sabile; Smith, Susan Y.; Ominsky, Michael S.; Hattersley, Gary (June 2017). "Comparing the incidence of bone tumors in rats chronically exposed to the selective PTH type 1 receptor agonist abaloparatide or PTH(1-34)". Regulatory Toxicology and Pharmacology. 86: 356–365. doi:10.1016/j.yrtph.2017.04.001. ISSN 1096-0295. PMID 28389324.
- "FDA Approves Radius Health's TYMLOS (abaloparatide), a Bone Building Agent for the Treatment of Postmenopausal Women with Osteoporosis at High Risk for Fracture" (Press release). Radius Inc. 28 April 2017. Archived from the original on 2017-11-04. Retrieved 2017-11-03.
- Tella, Sri Harsha; Kommalapati, Anuhya; Correa, Ricardo (2017-05-31). "Profile of Abaloparatide and Its Potential in the Treatment of Postmenopausal Osteoporosis". Cureus. 9 (5): e1300. doi:10.7759/cureus.1300. ISSN 2168-8184. PMC 5493470. PMID 28680788.
- Pioszak, Augen A.; Parker, Naomi R.; Gardella, Thomas J.; Xu, H. Eric (2009-10-09). "Structural Basis for Parathyroid Hormone-related Protein Binding to the Parathyroid Hormone Receptor and Design of Conformation-selective Peptides". The Journal of Biological Chemistry. 284 (41): 28382–28391. doi:10.1074/jbc.M109.022905. ISSN 0021-9258. PMC 2788887. PMID 19674967.
- Tay, D.; Cremers, S.; Bilezikian, J. P. (2017-10-19). "Optimal dosing and delivery of PTH and its analogues for osteoporosis and hypoparathyroidism - translating the pharmacology". British Journal of Clinical Pharmacology. doi:10.1111/bcp.13455. ISSN 1365-2125. PMC 5777439. PMID 29049872.
- Bahar, Hila; Gallacher, Kyla; Downall, Julie; Nelson, Carol A.; Shomali, Maysoun; Hattersley, Gary (2016). "Six Weeks of Daily Abaloparatide Treatment Increased Vertebral and Femoral Bone Mineral Density, Microarchitecture and Strength in Ovariectomized Osteopenic Rats". Calcified Tissue International. 99 (5): 489–499. doi:10.1007/s00223-016-0171-1. ISSN 0171-967X. PMC 5055567. PMID 27395059.
- Varela, Aurore; Chouinard, Luc; Lesage, Elisabeth; Smith, Susan Y.; Hattersley, Gary (January 2017). "One Year of Abaloparatide, a Selective Activator of the PTH1 Receptor, Increased Bone Formation and Bone Mass in Osteopenic Ovariectomized Rats Without Increasing Bone Resorption". Journal of Bone and Mineral Research. 32 (1): 24–33. doi:10.1002/jbmr.3003. ISSN 1523-4681. PMID 27748532.
- Varela, Aurore; Chouinard, Luc; Lesage, Elisabeth; Guldberg, Robert; Smith, Susan Y.; Kostenuik, Paul J.; Hattersley, Gary (February 2017). "One year of abaloparatide, a selective peptide activator of the PTH1 receptor, increased bone mass and strength in ovariectomized rats". Bone. 95: 143–150. doi:10.1016/j.bone.2016.11.027. ISSN 1873-2763. PMID 27894941.
- "Phase 2 Dose-finding Study to Evaluate the Effects of BA058 in the Treatment of Postmenopausal Women With Osteoporosis - Full Text View - ClinicalTrials.gov". Retrieved 2017-11-04.
- Leder, Benjamin Z.; O'Dea, Louis St L.; Zanchetta, José R.; Kumar, Prasana; Banks, Kathleen; McKay, Kathleen; Lyttle, C. Richard; Hattersley, Gary (February 2015). "Effects of abaloparatide, a human parathyroid hormone-related peptide analog, on bone mineral density in postmenopausal women with osteoporosis". The Journal of Clinical Endocrinology and Metabolism. 100 (2): 697–706. doi:10.1210/jc.2014-3718. ISSN 1945-7197. PMID 25393645.
- Clinical trial number NCT01343004 for "Phase III Study to Evaluate the Safety and Efficacy of BA058 for Prevention of Fracture in Postmenopausal Women" at ClinicalTrials.gov
- Miller, PD; Hattersley, G; Riis, BJ; Williams, GC; Lau, E; Russo, LA; Alexandersen, P; Zerbini, CA; Hu, MY; Harris, AG; Fitzpatrick, LA; Cosman, F; Christiansen, C; ACTIVE Study, Investigators. (16 August 2016). "Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial". JAMA. 316 (7): 722–33. doi:10.1001/jama.2016.11136. PMID 27533157.
- "Twenty Four Month Extension Study of BA058-05-003 - Full Text View - ClinicalTrials.gov". Retrieved 2017-11-04.
- Cosman, Felicia; Miller, Paul D.; Williams, Gregory C.; Hattersley, Gary; Hu, Ming-Yi; Valter, Ivo; Fitzpatrick, Lorraine A.; Riis, Bente Juel; Christiansen, Claus (February 2017). "Eighteen Months of Treatment With Subcutaneous Abaloparatide Followed by 6 Months of Treatment With Alendronate in Postmenopausal Women With Osteoporosis: Results of the ACTIVExtend Trial". Mayo Clinic Proceedings. 92 (2): 200–210. doi:10.1016/j.mayocp.2016.10.009. ISSN 1942-5546. PMID 28160873.
- Inc., Radius Health. "Radius Health Reports Third Quarter 2017 Financial and Operating Results and Provides Business Update". GlobeNewswire News Room. Retrieved 2017-11-03.
- "Radius Health Reports Third Quarter 2017 Financial and Operating Results and Provides Business Update". Yahoo Finances (Press release). GlobeNewswire. 2 November 2017. Archived from the original on 2017-11-07. Retrieved 2017-11-03.
- "Radius Health Announces License and Development Agreement for Abaloparatide-SC with Teijin Limited in Japan". Retrieved 2017-11-03.
- "Radius Health Has Submitted a Marketing Authorization Application for the Investigational Drug Abaloparatide-SC for the Treatment of Postmenopausal Osteoporosis in Europe". Retrieved 2017-11-03.
- "Radius Announces FDA Acceptance for Filing of New Drug Application for Abaloparatide-SC for the Treatment of Postmenopausal Women with Osteoporosis". Retrieved 2017-11-04.
- FDA (Apr 27, 2017). "NDA Approval Letter".
- "Abaloparatide | Patents | Expiry | Expiration | Dates | PharmaCompass.com". www.pharmacompass.com. Retrieved 2017-11-03.