AbbVie Inc.

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AbbVie Inc.
Public
Traded as NYSEABBV
S&P 100 component
S&P 500 component
Industry Biopharmaceutical
Founded 2013; 3 years ago (2013)
Headquarters Lake Bluff, Illinois, United States
Area served
Worldwide
(170+ Countries)
Key people
Richard A. Gonzalez
(Chairman & CEO)
Revenue Increase $22.859 billion (2015)[1]
Increase $7.537 billion (2015)[1]
Increase $5.144 billion (2015)[1]
Total assets Increase $53.050 billion (2015)[1]
Total equity Increase $3.945 billion (2015)[1]
Number of employees
28,000 (2015)
Website abbvie.com

AbbVie is a pharmaceutical company that discovers, develops and markets both biopharmaceuticals and small molecule drugs. It originated in 2013 as a spin-off of Abbott Laboratories.

History[edit]

On October 19, 2011, Abbott Laboratories announced its plan to separate into two publicly traded companies. The "new" Abbott Laboratories would specialize in diversified products including medical devices, diagnostic equipment and nutrition products, while AbbVie would operate as a research-based pharmaceutical manufacturer.[2] The separation was effective January 1, 2013, and AbbVie was officially listed on the New York Stock Exchange (ABBV) on January 2, 2013.[3]

According to the Miles White, CEO at the time, the purpose of the split was to allow markets to value the two businesses separately; White said that investors would "benefit from two fundamentally different investment opportunities with distinct strategic profiles and business priorities."[4] Some investors were concerned that the split was done to protect the value of the device business from the loss of value facing the drug division due to the imminent expiration of patents on Humira, which accounted for about half of the drug division's revenue.[4]

As of December 2015, the company employed in excess of 28,000 globally, and provided products to individuals in more than 170 countries.[5]

On September 3, 2014, AbbVie and Infinity Pharmaceuticals announced that they had entered into a global collaboration to develop and commercialize duvelisib, Infinity's PI3K inhibitor for the treatment of patients with cancer. On the same day, AbbVie and Calico announced that they had entered into a R&D collaboration intended to discover, develop and bring to market new therapies for patients with age-related diseases including neurodegeneration and cancer. Calico (California Life Company) is an Alphabet Inc. subsidiary led by Arthur D. Levinson (former Chairman and CEO of Genentech) and Hal V. Barron (former Executive Vice President and Chief Medical Officer of Genentech) that is focused on aging and age-related diseases.[6]

In October 2014, after a long negotiation, Abbvie stopped its efforts to acquire Shire, which would have been one of the largest M&A deals of that year; Abbvie had to pay a $1.6 billion breakup fee.[7]

On March 4, 2015, AbbVie announced its agreement to acquire the oncology firm Pharmacyclics and its treatment for blood cancers, ibrutinib; AstraZeneca had also been bidding to acquire Pharmacyclics.[8][9] Under the terms of the transaction, AbbVie agreed to pay $261.25 per share as a mix of cash and AbbVie equity. The acquisition valued at approximately $21 billion was completed on May 26, 2015.[10] The Pharmacyclics name was retained, and it operates as a subsidiary of AbbVie from its previous Sunnyvale, California, headquarters.[11] On June 3, 2015, AbbVie and Halozyme Therapeutics announced that they had entered into a global collaboration and licensing agreement to develop and commercialize products that combine AbbVie’s treatments and Halozyme’s ENHANZE drug-delivery technology, this was terminated in November 2016.[12]

According to the Wall Street Journal as of January 2016 ibrutinib, a specialty drug, cost US$116,600 to $155,400 a year wholesale in the United States. In spite of discounts and medical insurance, the prohibitive price causes some patients to not fill their prescriptions.[13] AbbVie estimates global sales of the drug at $1 billion in 2016 and $5 billion in 2020.[13]

On February 10, 2016, AbbVie and Cambridge, Massachusetts-based Synlogic announced a multi-year R&D collaboration. Synlogic is a synthetic biology company built on research from the labs of James Collins and Tim Lu at MIT. As part of the collaboration, AbbVie is getting worldwide rights to Synlogic’s probiotic-based technology for treating inflammatory bowel disease, and the research teams will focus on Crohn’s disease and ulcerative colitis.[14] In April 2016, the company partnered with the University of Chicago to investigate a number of areas of oncology: breast, lung, prostate, colorectal and hematological cancers.[15] In the same month the company announced it would co-commercialize Argenx's preclinical immunotherapy, ARGX-115. ARGX-115 is a first-in-class immunotherapy targeting GARP (glycoprotein A repetitions predominant), a membrane protein believed to enhance the immunosuppressive effects of T cells.[16] The company also announced a deal to co-develop/commercialize at least one of CytomX Probody's conjugates against CD71 (transferrin receptor 1).[17]

On 28 April 2016, the company announced it would acquire Stemcentrx for up to $9.8 billion.[18] A day later, the company announced an expansion of a two and a half year old cystic fibrosis deal with Galapagos, potentially doubling milestone payments to $600 million.[19]

Acquisitions[edit]

The following is an illustration of the company's major mergers and acquisitions and historical predecessors (this is not a comprehensive list):

AbbVie Inc

Pharmacyclics



Stemcentrx



Products[edit]

AbbVie developed adalimumab, which is marketed under the trade name Humira, a biopharmaceutical treatment for autoimmune diseases that has exceeded $10 billion in global sales. AbbVie’s portfolio of medicines also includes AndroGel, Creon, Duodopa and Duopa, Kaletra, Lupron, Niaspan, Norvir, Sevoflurane, Synagis, Synthroid, TriCor and Trilipix, Viekira and Zemplar.

See also[edit]

References[edit]

  1. ^ a b c d e "ABBV Annual Report Filing". morningstar.com. Retrieved 1 January 2016. 
  2. ^ "Abbott Labs to Split Into 2 Companies". The New York Times. October 19, 2011. Retrieved October 19, 2011. 
  3. ^ "Abbott Completes Separation of Research-Based Pharmaceuticals Business". AbbVie Inc. January 2, 2013. Retrieved January 2, 2013. 
  4. ^ a b "More than splitting pills: Health care giant Abbott Laboratories ready to spin off AbbVie". Chicago Tribune. December 30, 2012. Retrieved October 25, 2016. 
  5. ^ "AbbVie - About Us". abbvie.com. Retrieved 1 January 2016. 
  6. ^ "Google-Backed Calico Joins AbbVie in Up to $1.5B Collaboration". Genetic Engineering & Biotechnology News. September 3, 2014. Retrieved June 4, 2015. 
  7. ^ Gelles, David (2014). "After Tax Inversion Rules Change, AbbVie and Shire Agree to Terminate Their Deal". The New York Times (online, October 20 ed.). Zacks Equity Research. 
  8. ^ Nisen, Max (2015). "AstraZeneca Chases AbbVie, Cheaply". Chicago Business (online, December 17 ed.). Crain's. Retrieved 31 December 2015. 
  9. ^ Staff (1 April 2015). "AbVie Acquires Oncology Drug Firm Pharmacyclics for $21B". News: Industry Watch. Genetic Engineering & Biotechnology News (Paper). 35 (5): 10. 
  10. ^ Rockoff, Jonathan D.; Loftus, Peter (5 March 2015). "AbbVie to Buy Pharmacyclics in $21 Billion Deal". The Wall Street Journal. Retrieved 4 June 2015. (subscription required)
  11. ^ "AbbVie (ABBV) Announces Completion of Pharmacyclics Acquisition". StreetInsider.com. May 26, 2015. Retrieved June 5, 2015. 
  12. ^ http://www.genengnews.com/gen-news-highlights/abbvie-terminates-development-deal-with-halozyme/81253454
  13. ^ a b Walker, Joseph (1 January 2016). "Patients Struggle With High Drug Prices". Wall Street Journal. Retrieved 1 January 2016. 
  14. ^ "AbbVie, Maker of World's No. 1 Drug, Bets Synthetic Biology Startup Can Raise the Bar". February 10, 2016. Retrieved February 10, 2016. 
  15. ^ "AbbVie, University of Chicago Launch Cancer Research Alliance". GEN. 
  16. ^ "AbbVie to Co-Develop argenx's Cancer Immunotherapy ARGX-115 - GEN News Highlights - GEN". GEN. 
  17. ^ "AbbVie to Co-Commercialize CytomX's Probody Drug Conjugates". GEN. 
  18. ^ "AbbVie to Acquire Stemcentrx for Up to $9.8B". GEN. 
  19. ^ "Galapagos, AbbVie Expand CF Collaboration to Up-to-$600M". GEN. 

External links[edit]