Abe was the seventh son of "a Yiddish-speaking animal skinner who had fled Russia in 1889 to escape the pogroms and found work in the Gansevoort Street meatpacking district by the docks of the Lower West Side. Born in 1898, the boy had grown up in a cold-water flat on East Forty-ninth Street... He was a scappy kid, compact and solidly built...":34
The William Morris Agency hired Abe Lastfogel in 1912 as an office boy. Finding success in the rapidly growing firm, Lastfogel ultimately moved to Hollywood in 1932 to manage WMA's Los Angeles office. He was Chairman of William Morris.
During World War II, Lastfogel served as President of the USO-Camp Shows. In this capacity, he mounted wartime entertainment events with more than 7,000 performers—including Humphrey Bogart, James Cagney, Gary Cooper, Bing Crosby, Dinah Shore and James Stewart—to two hundred million soldiers, sailors, airmen and marines around the world.:82 
In 1927, Lastfogel married Frances Lastfogel (née Arms), a former vaudeville performer. They had no children.
- "Abe Lastfogel, Agent, Dead; A William Morris Executive". The New York Times. 27 August 1984. Retrieved 2 October 2015.
- Rose, Frank (1996). The Agency: William Morris and the Hidden History of Show Business (1st pbk. ed.). New York: HarperBusiness. ISBN 978-0-887-30807-9. OCLC 37128759.
- Buckley, Tom (3 December 1973). "William Morris Agency Marks 75 Years of 10% vaudeville headliner when". The New York Times. pp. 77, 85. Retrieved 2 October 2015.
- "USO Camp Show Head Back from England: Lastfogel Arrives on Clipper After Entertainment Survey". The New York Times. 17 December 1942. p. 42. Retrieved 2 October 2015.
- Kahn, Jr., E. J. (20 April 1946). "The Quiet Guy in Lindy's". The New Yorker. p. 35. Retrieved 2 October 2015.
- Kahn, Jr., E. J. (27 April 1946). "The Quiet Guy in Lindy's II". The New Yorker. p. 27. Retrieved 2 October 2015.
- "Abraham Lastfogel - United States Social Security Death Index". FamilySearch. Retrieved 2 October 2015.
- Rose, Frank. The Agency: William Morris and the Hidden History of Show Business. New York: HarperCollins, 1995. ISBN 978-0-887-30807-9 OCLC 37128759