Abetimus (trade name Riquent) is an immunosuppressant. It is a synthetic biological called a tolerogen. It is made of four double-stranded oligodeoxyribonucleotides that are attached to a carrier platform and are designed to block specific B-cell anti double stranded DNA antibodies. It may also complex anti dsDNA antibodies together, therefore disabling them. This way abetimus was supposed to help treat systemic lupus erythematosus and specifically lupus nephritis.
It was developed by La Jolla Pharmaceutical, who applied for marketing authorisations in the mid-2000s, but the drug was never marketed in the US or in Europe.
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- ^ Wallace, Daniel J. (January 2001), "Clinical and pharmacological experience with LJP-394", Expert Opinion on Investigational Drugs, Informa, 10 (1), pp. 111–117, ISSN 1354-3784, PMID 11116284, doi:10.1517/135437188.8.131.52, retrieved 2 April 2011
- ^ "Riquent Approval Status". Drugs.com. Retrieved 7 January 2017.
- ^ "Riquent". European Medicines Agency. Retrieved 7 January 2017.