Afterwards, he took part in the persecution against Chrysostom, and again compromised himself by ordaining as successor to Flavian, Porphyrius, a man considered unworthy of the episcopate and also a meletian. He defended Nestorius against Saint Cyril when the former was charged with heresy, though was not himself present at the Council of Ephesus. At a great age, he labored to reconcile Cyril of Alexandria and the Eastern Bishops at a Synod held at Beroea in 432 AD.
He died 437 AD, at the age of 116 years. Three of his letters remain in the original Greek, one to Cyril, and two to Alexander, Bishop of Hierapolis. (Ibid, pp. 819, 830, c.41.55. §129, 143.)