|Traded as||NASDAQ: XLRN|
|Headquarters||Cambridge, Massachusetts, United States|
|Footnotes / references
Acceleron Pharma, Inc. is a public American "clinical stage biopharmaceutical company" based in Boston, Massachusetts with a broad focus on developing medicines that regulate the transforming growth factor beta (TGF-β) superfamily of proteins, which play fundamental roles in the growth and repair of cells and tissues such as red blood cells, muscle, bone, and blood vessels.
Acceleron has four drugs in clinical trials, and one in preclinical development.
- Luspatercept (ACE-536) for anemia
- Sotatercept (ACE-011) for kidney disease
- Dalantercept (ACE-041) for kidney cancer
- ACE-083 for muscular disorders
The founders were scientists Jasbir Seehra, Tom Maniatis, Mark Ptashne, Wylie Vale, and scientific advisor Joan Massague, and business people and investors John Knopf and Christoph Westphal of Polaris Venture Partners, who served as founding CEO. The company was founded to discover and develop drugs based on the scientific discoveries of the scientific founders in the field of growth factors and transforming growth factors in the fields of metabolic disorders like obesity, diabetes, osteoporosis, and muscle-wasting conditions.
Glenn Batchelder was appointed president and CEO in June 2004.
It started its first clinical trial in June 2006; the product was ACE-011 (which eventually was named "sotatercept"), a protein therapeutic that was an activin type 2 receptor antagonist intended to treat bone loss. ACE-011 was a chimeric protein, created by fusing the binding portion of the activin type 2 receptor to part of an antibody; the resulting protein binds to activin and prevents it from acting.
Knopf took over as CEO in 2007. He became known for showing pictures of a Belgian Blue cow to potential inventors, as a way of illustrating the company's products' potential to develop muscle.
In 2008 Acceleron and Celgene started a partnership to jointly develop and market ACE-011 in which Celgene paid Acceleron $50 million up front and bought $5 million of Acceleron stock, and agreed to buy $7 million more in stock if Acceleron went public, and agreed to pay up to $510 million in milestones. In a separate deal done at the same time, Celgene acquired an option to license three products in Acceleron's pipeline directed to cancer and cancer-related bone loss.
In 2011 Acceleron extended its their partnership with Celgene to include ACE-536, a development candidate for anemia; Celgene paid $25 million upfront, with potential downstream payments of $217 million in milestones and royalties over 10%.
The company held its initial public offering in September 2013. At that time, the company had three protein therapeutic candidates being studied in 12 Phase 2 clinical trials, including sotatercept and luspatercept (ACE-536) which promoted red blood cell production and were being tested as potential treatments for anemia in people with thalassemia and myelodysplastic syndromes (MDS); its other candidate was dalantercept (ACE-041), an angiogenesis inhibitor as a potential cancer drug.
In September 2016 Knopf retired and the company hired Habib Dable as CEO; at that time the company's lead product luspatercept was in Phase III testing for MDS and beta-thalassemia.
- "What Are Some Of The Most Interesting Insights Gained From Serving On A Corporate Board That Have Made You A Better Leader?". Life Science Leader. VertMarkets. September 8, 2017. Retrieved September 28, 2017.
Francois is chairman of the board at Acceleron Pharma.
- "Luspatercept". AdisInsight. Retrieved 15 February 2017.
- "Sotatercept". AdisInsight. Retrieved 15 February 2017.
- "Dalantercept". AdisInsight. Retrieved 15 February 2017.
- "ACE 083". AdisInsight. Retrieved 15 February 2017.
- "ACE-2494 - Product Profile". BioCentury. Retrieved 15 February 2017.
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- McLellan, Dennis (January 18, 2012). "Wylie W. Vale Jr. dies at 70; researcher helped discover stress hormone". Los Angeles Times.
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- Huggett, Brady (December 2013). "Burning Bright". Nature Biotechnology. 31 (12). pp. 1068–71.
- Lawrence, Stacy (September 28, 2016). "Bayer commercial vet heads to Acceleron as it preps for PhIII Celgene data". FierceBiotech.