ACE inhibitor and thiazide combination

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An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension. They are given by oral administration.

Examples[edit]

Quinapril/hydrochlorothiazide
Combination of
QuinaprilAngiotensin converting enzyme inhibitor
HydrochlorothiazideThiazide diuretic
Clinical data
Trade namesAccuretic
AHFS/Drugs.comMultum Consumer Information
Pregnancy
category
  • US: D (Evidence of risk)
ATC code
Legal status
Legal status
Identifiers
ChemSpider
KEGG
Lisinopril/hydrochlorothiazide
Combination of
LisinoprilACE inhibitor
HydrochlorothiazideThiazide diuretic
Clinical data
MedlinePlusa601070
Pregnancy
category
  • US: D (Evidence of risk)
Routes of
administration
Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
KEGG
  (verify)

Fosinopril/hydrochlorothiazide[edit]

Fosinopril/hydrochlorothiazide
Combination of
FosinoprilAngiotensin converting enzyme inhibitor
HydrochlorothiazideThiazide diuretic
Clinical data
Trade namesMonopril HCT
Pregnancy
category
  • C (1st trimester); D (2nd & 3rd trimesters)
Routes of
administration
Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)

Fosinopril/hydrochlorothiazide (trade name Monopril HCT) has a boxed warning about its significant risk to cause fetal/neonatal morbidity and mortality when being used during pregnancy (2nd and 3rd trimesters).[4]

FDA modified its labeling on February, 2009 to include a precaution of drug interaction with gold. "Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and hypotension) have been reported rarely in patients on therapy with injectable gold (sodium aurothiomalate) and concomitant ACE inhibitor therapy including Monopril/Monopril HCT."[5]

See also[edit]

References[edit]

  1. ^ Accuretic Multum Consumer Information
  2. ^ "Prinzide Uses, Side Effects & Warnings - Drugs.com". drugs.com.
  3. ^ "Zestoretic: Uses, Dosage & Side Effects - Drugs.com". drugs.com.
  4. ^ "fosinopril/hydrochlorothiazide (Rx) - Contraindications & Cautions". Medscape. Retrieved 13 December 2013.
  5. ^ "Monopril HCT (fosinopril/hydrochlorothiazide) 20/12.5mg and 10/12.5mg Tablets February 2009". FDA.