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Systematic (IUPAC) name
2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
Clinical data
AHFS/ International Drug Names
Legal status
Legal status
  • UK: POM (Prescription only)
CAS Number 53164-05-9 YesY
ATC code M01AB11 (WHO)
PubChem CID 1981
ChemSpider 1904 YesY
UNII 5V141XK28X YesY
KEGG D01582 YesY
Chemical data
Formula C21H18ClNO6
Molar mass 415.82372 g/mol

Acemetacin is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain. It is manufactured by Merck KGaA under the tradename Emflex, and is available in the UK as a prescription-only drug. Other brand names for acemetacin include Zadex (Hungary), Rheutrop (Austria), Acemetadoc, Acephlogont, Azeat, Rantudil (Germany, Hungary, Mexico, Portugal, Turkey), Gamespir (Greece), Oldan, Reudol (Spain), Tilur (Switzerland), Ost-map (Egypt).

Acemetacin, a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects. An advantage of acemetacin is that it reduces gastric damage when compared to indometacin.