Acenocoumarol

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Acenocoumarol
Acenocoumarol.svg
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy
category
  • X
Routes of
administration
Oral
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
Pharmacokinetic data
Metabolism Hepatic
Biological half-life 8 to 11 hours
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.005.281
Chemical and physical data
Formula C19H15NO6
Molar mass 353.326 g/mol
3D model (JSmol)
Chirality Racemic mixture
Melting point 196 to 199 °C (385 to 390 °F)
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Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is generic, so is marketed under many brand names worldwide.[1]

References[edit]

External links[edit]

  • Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol.". Blood Coagul Fibrinolysis. 15 (8): 673–6. PMID 15613922. doi:10.1097/00001721-200412000-00007. 
  • Lengyel M; SPORTIF-III Altanulmány Vizsgálói (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil. 145 (52): 2619–21. PMID 15724697. 
  • Ufer M (2005). "Comparative pharmacokinetics of vitamin Kd antagonists: warfarin, phenprocoumon and acenocoumarol.". Clin Pharmacokinet. 44 (12): 1227–46. PMID 16372822. doi:10.2165/00003088-200544120-00003. 
  • Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients.". Br J Haematol. 133 (2): 183–7. PMID 16611310. doi:10.1111/j.1365-2141.2006.06007.x.