Acetoacetate—CoA ligase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
acetoacetate-CoA ligase
Identifiers
EC number 6.2.1.16
CAS number 39394-62-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an acetoacetate-CoA ligase (EC 6.2.1.16) is an enzyme that catalyzes the chemical reaction

ATP + acetoacetate + CoA AMP + diphosphate + acetoacetyl-CoA

The 3 substrates of this enzyme are ATP, acetoacetate, and CoA, whereas its 3 products are AMP, diphosphate, and acetoacetyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acetoacetate:CoA ligase (AMP-forming). This enzyme is also called acetoacetyl-CoA synthetase. This enzyme participates in butanoate metabolism.

References[edit]