Acetoacetyl-CoA

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Acetoacetyl-CoA
Acetoacetyl coenzyme A.svg
Identifiers
3D model (Jmol)
ChEBI
ChemSpider
ECHA InfoCard 100.014.378
MeSH acetoacetyl+CoA
Properties
C25H40N7O18P3S
Molar mass 851.609 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway, which is essential for cholesterol biosynthesis. It also takes a similar role in the ketone bodies synthesis (ketogenesis) pathway of the liver. In the ketone bodies digestion pathway (in the tissue), it is no longer associated with having HMG-CoA as a product or as a reactant.

It is created from acetyl-CoA by thiolase, and it is acted upon by HMG-CoA synthase to form HMG-CoA. During the metabolism of leucine, this last reaction is reversed.

Mevalonate pathway

See also[edit]