acetone or propanone
|Systematic IUPAC name
|Molar mass||58.08 g·mol−1|
|Odor||pungent, irritating, floral|
|Density||0.791 g cm−3|
|Melting point||−95 to −93 °C; −139 to −136 °F; 178 to 180 K|
|Boiling point||56 to 57 °C; 133 to 134 °F; 329 to 330 K|
|Solubility||miscible in benzene, diethyl ether, methanol, chloroform, ethanol|
|Vapor pressure||9.39 kPa (0 °C)
30.6 kPa (25 °C)
374 kPa (100 °C)
2.8 MPa (200 °C)
|Basicity (pKb)||-5.2 (for conjugate base)|
Refractive index (nD)
|Viscosity||0.36 (10 °C)
0.295 cP (25 °C)
|Trigonal planar at C2|
|Dihedral at C2|
Std enthalpy of
Std enthalpy of
|Safety data sheet||See: data page|
|GHS signal word||DANGER|
|H225, H319, H336|
|P210, P261, P305+351+338|
|EU classification||F Xi|
|R-phrases||R11, R36, R66, R67|
|S-phrases||(S2), S9, S16, S26|
|Flash point||−20 °C (−4 °F; 253 K)|
|465 °C (869 °F; 738 K)|
|1185 mg/m3 (TWA), 2375 mg/m3 (STEL)|
|Lethal dose or concentration (LD, LC):|
LD50 (Median dose)
|5800 mg/kg (rat, oral)
3000 mg/kg (mouse, oral)
5340 mg/kg (rabbit, oral)
LC50 (Median concentration)
|20,702 ppm (rat, 8 hr)|
|US health exposure limits (NIOSH):|
|1000 ppm (2400 mg/m3)|
|TWA 250 ppm (590 mg/m3)|
IDLH (Immediate danger
|Supplementary data page|
|Refractive index (n),
Dielectric constant (εr), etc.
|UV, IR, NMR, MS|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is: / ?)(|
- This is about the chemical compound. For the band, see Acetone (band).
Acetone is miscible with water and serves as an important solvent in its own right, typically for cleaning purposes in the laboratory. About 6.7 million tonnes were produced worldwide in 2010, mainly for use as a solvent and production of methyl methacrylate and bisphenol A. It is a common building block in organic chemistry. Familiar household uses of acetone are as the active ingredient in nail polish remover and as paint thinner.
Acetone is produced and disposed of in the human body through normal metabolic processes. It is normally present in blood and urine. People with diabetes produce it in larger amounts. Reproductive toxicity tests show that it has low potential to cause reproductive problems. Pregnant women, nursing mothers and children have higher levels of acetone. Ketogenic diets that increase acetone in the body are used to counter epileptic attacks in infants and children who suffer from recalcitrant refractory epilepsy.
- 1 History
- 2 Metabolism
- 3 Production
- 4 Uses
- 5 Safety
- 6 Environmental effects
- 7 Extraterrestrial occurence
- 8 References
- 9 External links
Acetone was first produced by alchemists during the late middle ages via the dry distillation of metal acetates (e.g., lead acetate, which produced "spirit of Saturn" (since the alchemical symbol for lead was also the astrological symbol for the planet Saturn)). In 1832, French chemist Jean Baptiste Dumas and German chemist Justus von Liebig determined the empirical formula for acetone. In 1833, the French chemist Antoine Bussy named acetone by adding the suffix -one to the stem of the corresponding acid (viz, acetic acid). By 1852, English chemist Alexander William Williamson realized that acetone was methyl acetyl; the following year, the French chemist Charles Frédéric Gerhardt concurred. In 1865, the German chemist August Kekulé published the modern structural formula for acetone.
Small amounts of acetone are produced in the body by the decarboxylation of ketone bodies. Certain dietary patterns, including prolonged fasting and high-fat low-carbohydrate dieting, can produce ketosis, in which acetone is formed in body tissue. Certain health conditions, such as alcoholism and diabetes, can produce ketoacidosis, uncontrollable ketosis that leads to a sharp, and potentially fatal, increase in the acidity of the blood. Since it is a byproduct of fermentation, acetone is a byproduct of the distillery industry.
Although some biochemistry textbooks and current research publications indicate that acetone cannot be metabolized, there is evidence to the contrary, some dating back thirty years. Acetone can be produced from the oxidation of ingested isopropanol, or from the spontaneous/enzymatic breakdown of acetoacetate (a ketone body) in ketotic individuals. It can then be metabolized either by CYP2E1 via methylglyoxal to D-lactate and pyruvate, and ultimately glucose/energy, or by a different pathway via propylene glycol to pyruvate, lactate, acetate (usable for energy) and propionaldehyde.
In 2010, the worldwide production capacity for acetone was estimated at 6.7 million tonnes per year. With 1.56 million tonnes per year, the United States had the highest production capacity, followed by Taiwan and mainland China. The largest producer of acetone is INEOS Phenol, owning 17% of the world's capacity, with also significant capacity (7–8%) by Mitsui, Sunoco and Shell in 2010. INEOS Phenol also owns the world's largest production site (420,000 tonnes/annum) in Beveren (Belgium). Spot price of acetone in summer 2011 was 1100–1250 USD/tonne in the United States.
Acetone is produced directly or indirectly from propylene. Approximately 83% of acetone is produced via the cumene process; as a result, acetone production is tied to phenol production. In the cumene process, benzene is alkylated with propylene to produce cumene, which is oxidized by air to produce phenol and acetone:
- Ca(CH3COO)2 → CaO(s) + CO2(g) + (CH3)2CO (v)
Before that, during World War I acetone was produced using acetone-butanol-ethanol fermentation with Clostridium acetobutylicum bacteria, which was developed by Chaim Weizmann (later the first president of Israel) in order to help the British war effort in the preparation of Cordite. This acetone-butanol-ethanol fermentation was eventually abandoned when newer methods with better yields were found.
Acetone is a good solvent for many plastics and some synthetic fibers. It is used for thinning polyester resin, cleaning tools used with it, and dissolving two-part epoxies and superglue before they harden. It is used as one of the volatile components of some paints and varnishes. As a heavy-duty degreaser, it is useful in the preparation of metal prior to painting. It is also useful for high reliability soldering applications to remove rosin flux after soldering is complete; this helps to prevent the rusty bolt effect.
Although itself flammable, acetone is used extensively as a solvent for the safe transportation and storage of acetylene, which cannot be safely pressurized as a pure compound. Vessels containing a porous material are first filled with acetone followed by acetylene, which dissolves into the acetone. One liter of acetone can dissolve around 250 liters of acetylene.
- (CH3)2CO + HCN → (CH3)2C(OH)CN
- (CH3)2C(OH)CN + CH3OH → CH2=(CH3)CCO2CH3 + NH3
The third major use of acetone (about 20%) is synthesizing bisphenol A. Bisphenol A is a component of many polymers such as polycarbonates, polyurethanes, and epoxy resins. The synthesis involves the condensation of acetone with phenol:
- (CH3)2CO + 2 C6H5OH → (CH3)2C(C6H4OH)2 + H2O
Many millions of kilograms of acetone are consumed in the production of the solvents methyl isobutyl alcohol and methyl isobutyl ketone. These products arise via an initial aldol condensation to give diacetone alcohol.
- 2 (CH3)2CO → (CH3)2C(OH)CH2C(O)CH3
In the laboratory, acetone is used as a polar, aprotic solvent in a variety of organic reactions, such as SN2 reactions. The use of acetone solvent is critical for the Jones oxidation. It does not form an azeotrope with water (see azeotrope (data)). It is a common solvent for rinsing laboratory glassware because of its low cost and volatility. Despite its common use as a supposed drying agent, it is not effective except by bulk displacement and dilution. Acetone can be cooled with dry ice to −78 °C without freezing; acetone/dry ice baths are commonly used to conduct reactions at low temperatures. Acetone is fluorescent under ultraviolet light, and its vapor may be used as a fluorescent tracer in fluid flow experiments.
Medical and cosmetic uses
Acetone is used in a variety of general medical and cosmetic applications and is also listed as a component in food additives and food packaging. Dermatologists use acetone with alcohol for acne treatments to peel dry skin.
Acetone is commonly used in chemical peeling. Common agents used today for chemical peels are salicylic acid, glycolic acid, 30% salicylic acid in ethanol, and trichloroacetic acid (TCA). Prior to chemexfoliation, the skin is cleaned and excess fat removed in a process called defatting. Acetone, Septisol, or a combination of these agents is commonly used in this process.
Domestic and other niche uses
Acetone is often the primary component in cleaning agents such as nail polish remover. Acetone is a component of superglue remover and easily removes residues from glass and porcelain. Make-up artists use acetone to remove skin adhesive from the netting of wigs and moustaches by immersing the item in an acetone bath, then removing the softened glue residue with a stiff brush.
This chemical is also used as an artistic agent; when rubbed on the back of a laser print or photocopy placed face-down on another surface and burnished firmly, the toner of the image transfers to the destination surface.[original research?]
Acetone can also be used in combination with automatic transmission fluid to create an effective penetrating oil. Brake fluid is sometimes used in place of ATF. These mixtures (usually 1:1) can be useful in loosening rusted or stuck bolts.
Acetone is often used by people in the 3d printing community to smooth out printing artifacts on models printed using ABS plastic. The technique called "acetone vapor bath smoothing" involves imersing the printed part in a sealed container containing a small amount (about 10ml) of acetone, and heated to around 80c for about 10 minutes. This creates a vapor fog in the container. The acetone vapor condenses evenly all over the part, causing the surface to soften and liquify. The semi liquid plastic then self levels, and then the acetone component evaporates, leaving a glassy smooth part free of all striation, patterning, and visible layer edges typically the hallmark of a 3d printed part.
The most hazardous property of acetone is its extreme flammability. At temperatures greater than acetone's flash point of −20 °C (−4 °F), air mixtures of between 2.5% and 12.8% acetone, by volume, may explode or cause a flash fire. Vapors can flow along surfaces to distant ignition sources and flash back. Static discharge may also ignite acetone vapors, though acetone has a very high ignition initiation energy point and therefore accidental ignition is rare. Even pouring or spraying acetone over red-glowing coal will not ignite it, due to the high concentration of vapour and the cooling effect of evaporation of the liquid. It auto-ignites at 465 °C (869 °F). Auto-ignition temperature is also dependent upon the exposure time, thus at some tests it is quoted as 525 °C. Also, industrial acetone is likely to contain a small amount of water which also inhibits ignition.
When oxidized, acetone forms acetone peroxide as a byproduct, which is a highly unstable, primary high explosive compound. It may be formed accidentally, e.g. when waste hydrogen peroxide is poured into waste solvent containing acetone. Due to its instability, it is rarely used, despite its easy chemical synthesis.
Acetone has been studied extensively and is generally recognized to have low acute and chronic toxicity if ingested and/or inhaled. Acetone is not currently regarded as a carcinogen, a mutagenic chemical or a concern for chronic neurotoxicity effects.
Acetone can be found as an ingredient in a variety of consumer products ranging from cosmetics to processed and unprocessed foods. Acetone has been rated as a generally recognized as safe (GRAS) substance when present in beverages, baked foods, desserts, and preserves at concentrations ranging from 5 to 8 mg/L.
Acetone is believed to exhibit only slight toxicity in normal use, and there is no strong evidence of chronic health effects if basic precautions are followed.
At very high vapor concentrations, acetone is irritating and, like many other solvents, may depress the central nervous system. It is also a severe irritant on contact with eyes, and a potential pulmonary aspiration risk. In one documented case, ingestion of a substantial amount of acetone led to systemic toxicity, although the patient eventually fully recovered. Some sources estimate LD50 for human ingestion at 0.621 g/kg; LD50 inhalation by mice is given as 23 g/m3, over 4 hours.
Acetone has been shown to have anticonvulsant effects in animal models of epilepsy, in the absence of toxicity, when administered in millimolar concentrations. It has been hypothesized that the high-fat low-carbohydrate ketogenic diet used clinically to control drug-resistant epilepsy in children works by elevating acetone in the brain.
- EPA EPCRA Delisting (1995). EPA removed acetone from the list of "toxic chemicals" maintained under Section 313 of the Emergency Planning and Community Right to Know Act (EPCRA). In making that decision, EPA conducted an extensive review of the available toxicity data on acetone and found that acetone "exhibits acute toxicity only at levels that greatly exceed releases and resultant exposures", and further that acetone "exhibits low toxicity in chronic studies".
- Genotoxicity. Acetone has been tested in more than two dozen in vitro and in vivo assays. These studies indicate that acetone is not genotoxic.
- Carcinogenicity. EPA in 1995 concluded, "There is currently no evidence to suggest a concern for carcinogenicity". (EPCRA Review, described in Section 3.3). NTP scientists have recommended against chronic toxicity/carcinogenicity testing of acetone because "the prechronic studies only demonstrated a very mild toxic response at very high doses in rodents".
- Neurotoxicity and Developmental Neurotoxicity. The neurotoxic potential of both acetone and isopropanol, the metabolic precursor of acetone, have been extensively studied. These studies demonstrate that although exposure to high doses of acetone may cause transient central nervous system effects, acetone is not a neurotoxicant. A guideline developmental neurotoxicity study has been conducted with isopropanol, and no developmental neurotoxic effects were identified, even at the highest dose tested. (SIAR, pp. 1, 25, 31).
- Environmental. When the EPA exempted acetone from regulation as a volatile organic compound (VOC) in 1995, EPA stated that this exemption would "contribute to the achievement of several important environmental goals and would support EPA's pollution prevention efforts". 60 Fed. Reg. 31,634 (June 16, 1995). 60 Fed. Reg. 31,634 (June 16, 1995). EPA noted that acetone could be used as a substitute for several compounds that are listed as hazardous air pollutants (HAP) under section 112 of the Clean Air Act.
|This section requires expansion. (June 2015)|
Although acetone occurs naturally in the environment in plants, trees, volcanic gases, forest fires, and as a product of the breakdown of body fat, the majority of the acetone released into the environment is of industrial origin. Acetone evaporates rapidly, even from water and soil. Once in the atmosphere, it has a 22-day half-life and is degraded by UV light via photolysis (primarily into methane and ethane.) Consumption by microorganisms contributes to the dissipation of acetone in soil, animals, or waterways. The LD50 of acetone for fish is 8.3 g/L of water (or about 1%) over 96 hours, and its environmental half-life in water is about 1 to 10 days. Acetone may pose a significant risk of oxygen depletion in aquatic systems due to the microbial consumption.
On 30 July 2015, scientists reported that upon the first touchdown of the Philae lander on comet 67/P 's surface, measurements by the COSAC and Ptolemy instruments revealed sixteen organic compounds, four of which were seen for the first time on a comet, including acetamide, acetone, methyl isocyanate and propionaldehyde.
- The Merck Index, 15th Ed. (2013), p. 13, Acetone Monograph 65, O'Neil: The Royal Society of Chemistry.(subscription required)
- "Acetone". NIST Chemistry WebBook. USA: National Institute of Standards and Technology.
- Klamt, Andreas (2005). COSMO-RS: From Quantum Chemistry to Fluid Phase Thermodynamics and Drug Design. Elsevier. pp. 92–94. ISBN 978-0-444-51994-8.
- Ash, Michael; Ash, Irene (2004). Handbook of preservatives. Synapse Information Resources, Inc. p. 369. ISBN 1-890595-66-7.
- Myers, Richard L. (2007). The 100 Most Important Chemical Compounds: A Reference Guide. Greenwood. pp. 4–6. ISBN 978-0-313-08057-9.
- "NIOSH Pocket Guide to Chemical Hazards #0260". National Institute for Occupational Safety and Health (NIOSH).
- "Acetone". PubChem. USA: National Center for Biotechnology Information.
- Acetone in Linstrom, P.J.; Mallard, W.G. (eds.) NIST Chemistry WebBook, NIST Standard Reference Database Number 69. National Institute of Standards and Technology, Gaithersburg MD. http://webbook.nist.gov (retrieved 2014-05-11)
- Working with modern hydrocarbon and oxygenated solvents: a guide to flammability American Chemistry Council Solvents Industry Group, pg. 7, January 2008
- "Acetone". Immediately Dangerous to Life and Health. National Institute for Occupational Safety and Health (NIOSH).
- Acetone, World Petrochemicals report, January 2010
- Stylianos Sifniades, Alan B. Levy, "Acetone" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2005.
- American Chemistry Council, Acetone VCCEP Submission, September 10, 2003, page 9
- Mel Gorman and Charles Doering (1959) "History of the structure of acetone," Chymia, 5 : 202-208.
- J. Dumas (1832) "Sur l'esprit pyro-acétique" (On pyro-acetic spirit), Annales de Chimie et de Physique, 2nd series, 49 : 208-210.
- Justus Liebig (1832) "Sur les combinaisons produites par l'action du gas oléfiant et l'esprit acétique" (On compounds produced by the action of ethylene and acetic spirit), Annales de Chimie et de Physique, 2nd series, 49 : 146-204 ; see especially pp. 193-204.
- Antoine Bussy (1833) "De quelques Produits nouveaux obtenus par l’action des Alcalis sur les Corps gras à une haute température" (On some new products obtained by the action of alkalies on fatty substances at a high temperature), Annales de Chimie et de Physique, 2nd series, 53 : 398–412 ; see footnote on p. 409, continued from p. 408.
- A. W. Williamson (1852) "On Etherification," Journal of the Chemical Society, 4 : 229-239 ; see especially pp. 237-239.
- Charles Gerhardt (1853) "Researches sur les acids organiques anhydres" (Research on anhydrous organic acids), Annales de Chimie et de Physique, 3rd series, 37 : 285- 342 ; see p. 339.
- Auguste Kekulé (1865) "Sur la constitution des substances aromatiques," Bulletin de la Société chimique de Paris, 1 : 98-110 ; see especially p. 110.
- Auguste Kekulé (1866) "Untersuchungen über aromatischen Verbindungen" (Investigations into aromatic compounds), Annalen der Chemie und Pharmacie, 137 : 129-196 ; see especially pp. 143-144.
- Note: Johann Josef Loschmidt had presented the structure of acetone in 1861, but his privately published booklet received little attention. See: J. Loschmidt, Chemische Studien (Vienna, Austria-Hungary: Carl Gerold's Sohn, 1861).
- M Vujasinović; M Kočar; K Kramer; M Bunc; M Brvar. "Poisoning with 1-propanol and 2-propanol". Retrieved March 2014.
- Glew, Robert H. "You Can Get There From Here: Acetone, Anionic Ketones and Even-Carbon Fatty Acids can Provide Substrates for Gluconeogenesis". Retrieved August 2013.
- Miller DN, Bazzano G; Bazzano (1965). "Propanediol metabolism and its relation to lactic acid metabolism". Ann NY Acad Sci 119 (3): 957–973. Bibcode:1965NYASA.119..957M. doi:10.1111/j.1749-6632.1965.tb47455.x. PMID 4285478.
- Ruddick JA (1972). "Toxicology, metabolism, and biochemistry of 1,2-propanediol". Toxicol App Pharmacol 21: 102–111. doi:10.1016/0041-008X(72)90032-4.
- Camara Greiner, EO and Funada, C (June 2010). "CEH Marketing Research Report: ACETONE". Chemical Economics Handbook. SRI consulting. Retrieved March 2011.
- "Acetone Uses and Market Data". ICIS.com. October 2010. Retrieved 2011-03-21.
- Acetone (US Gulf) Price Report – Chemical pricing information. ICIS Pricing. Retrieved on 2012-11-26.
- Wittcoff, M.M. Green ; H.A. (2003). Organic chemistry principles and industrial practice (1. ed., 1. reprint. ed.). Weinheim: Wiley-VCH. p. 4. ISBN 3-527-30289-1.
- Weiner, Myra L.; Lois A. Kotkoskie (1999). Excipient Toxicity and Safety. p. 32. ISBN 978-0-8247-8210-8.
- Inactive Ingredient Search for Approved Drug Products, FDA/Center for Drug Evaluation and Research
- Mine Safety and Health Administration (MSHA) – Safety Hazard Information – Special Hazards of Acetylene. Msha.gov. Retrieved on 2012-11-26.
- History – Acetylene dissolved in acetone. Aga.com. Retrieved on 2012-11-26.
- What is an Azeotrope?. Solvent—recycling.com. Retrieved on 2012-11-26.
- A. Lozano, B. Yip and R. K. Hanson (1992). "Acetone: a tracer for concentration measurements in gaseous flows by planar laser-induced fluorescence". Exp. Fluids 13 (6): 369–376. doi:10.1007/BF00223244.
- zuks, "Quality Finish 3D Prints with Acetone"
- Acetone MSDS. Hazard.com (1998-04-21). Retrieved on 2012-11-26.
- "SIDS Initial Assessment Report: Acetone" (PDF). Environmental Protection Agency.
- Basic Information on Acetone. Ccohs.ca (1999-02-19). Retrieved on 2012-11-26.
- Canadian Centre for Occupational Health and Safety. "Health Effects of Acetone". Archived from the original on 17 October 2008. Retrieved 2008-10-21.
- Safety (MSDS) data for propanone. Msds.chem.ox.ac.uk. Retrieved on 2012-11-26[dead link]
- Likhodii SS, Serbanescu I, Cortez MA, Murphy P, Snead OC 3rd, Burnham WM (2003). "Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet". Ann Neurol. 54 (2): 219–226. doi:10.1002/ana.10634. PMID 12891674.
- Acetone, Agency for Toxic Substances and Disease Registry ToxFAQs, 1995
- Darwent, B. deB.; Allard, M. J.; Hartman, M. F.; Lange, L. J. (1960). "The Photolysis of Acetone". Journal of Physical Chemistry 64 (12): 1847. doi:10.1021/j100841a010.
- Safety Data Sheet Acetone. jmloveridge.com. Retrieved on 2012-11-26.
- Jordans, Frank (30 July 2015). "Philae probe finds evidence that comets can be cosmic labs". The Washington Post. Associated Press. Retrieved 30 July 2015.
- "Science on the Surface of a Comet". European Space Agency. 30 July 2015. Retrieved 30 July 2015.
- Bibring, J.-P.; Taylor, M.G.G.T.; Alexander, C.; Auster, U.; Biele, J.; Finzi, A. Ercoli; Goesmann, F.; Klingehoefer, G.; Kofman, W.; Mottola, S.; Seidenstiker, K.J.; Spohn, T.; Wright, I. (31 July 2015). "Philae's First Days on the Comet - Introduction to Special Issue". Science (journal) 349 (6247): 493. doi:10.1126/science.aac5116. Retrieved 30 July 2015.
|Wikimedia Commons has media related to Acetone.|
- International Chemical Safety Card 0087
- NIOSH Pocket Guide to Chemical Hazards
- Acetone Safety Data Sheet (SDS)
- Hazardous substances databank entry at the national library of medicine
- SIDS Initial Assessment Report for Acetone from the Organisation for Economic Co-operation and Development (OECD)
- Calculation of vapor pressure, liquid density, dynamic liquid viscosity, surface tension of acetone