Acetyl chloride

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Acetyl chloride[1]
Skeletal formula of acetyl chloride
Ball-and-stick model of acetyl chloride
Space-filling model of acetyl chloride
Acetyl chloride 25ml.jpg
Names
Preferred IUPAC name
Acetyl chloride[2]
Systematic IUPAC name
Ethanoyl chloride
Other names
Acyl chloride
Identifiers
3D model (JSmol)
605303
ChEBI
ChemSpider
ECHA InfoCard 100.000.787 Edit this at Wikidata
EC Number
  • 200-865-6
1611
RTECS number
  • AO6390000
UNII
UN number 1717
  • InChI=1S/C2H3ClO/c1-2(3)4/h1H3 checkY
    Key: WETWJCDKMRHUPV-UHFFFAOYSA-N checkY
  • InChI=1/C2H3ClO/c1-2(3)4/h1H3
    Key: WETWJCDKMRHUPV-UHFFFAOYAQ
  • ClC(=O)C
Properties
CH3COCl
Molar mass 78.49 g/mol
Appearance Colorless liquid
Density 1.104 g/ml, liquid
Melting point −112 °C (−170 °F; 161 K)
Boiling point 52 °C (126 °F; 325 K)
Reacts with water
-38.9·10−6 cm3/mol
Structure
2.45 D
Hazards
GHS pictograms GHS02: FlammableGHS05: CorrosiveGHS07: Exclamation mark
GHS Signal word Danger
H225, H302, H314, H335, H412
P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P273, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P330, P363, P370+P378, P403+P233, P403+P235, P405, P501
NFPA 704 (fire diamond)
3
3
2
Flash point 4 °C (39 °F; 277 K)
390 °C (734 °F; 663 K)
Explosive limits 7.3–19%
Related compounds
Propionyl chloride
Butyryl chloride
Related compounds
Acetic acid
Acetic anhydride
Acetyl bromide
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)
Infobox references

Acetyl chloride (CH3COCl) is an acyl chloride derived from acetic acid. It belongs to the class of organic compounds called acyl halides. It is a colorless, corrosive, volatile liquid. Its formula is commonly abbreviated to AcCl.

Synthesis[edit]

On an industrial scale, the reaction of acetic anhydride with hydrogen chloride produces a mixture of acetyl chloride and acetic acid:[3]

(CH3CO)2O + HCl → CH3COCl + CH3CO2H

Laboratory routes[edit]

Acetyl chloride was first prepared in 1852 by French chemist Charles Gerhardt by treating potassium acetate with phosphoryl chloride.[4]


Acetyl chloride is produced in the laboratory by the reaction of acetic acid with chlorodehydrating agents such as PCl3, PCl5, SO2Cl2, phosgene, or SOCl2. However, these methods usually give acetyl chloride contaminated by phosphorus or sulfur impurities, which may interfere with the organic reactions.[5]

Other methods[edit]

When heated, a mixture of dichloroacetyl chloride and acetic acid gives acetyl chloride.[5] It can also be synthesized from the catalytic carbonylation of methyl chloride.[6] It also arises from the reaction of acetic acid, acetonitrile, and hydrogen chloride.[citation needed]

Occurrence[edit]

Acetyl chloride is not expected to exist in nature, because contact with water would hydrolyze it into acetic acid and hydrogen chloride. In fact, if handled in open air it releases white "smoke" resulting from hydrolysis due to the moisture in the air. The smoke is actually small droplets of hydrochloric acid and acetic acid formed by hydrolysis.

Uses[edit]

Acetyl chloride is used for acetylation reactions, i.e., the introduction of an acetyl group. Acetyl is an acyl group having the formula-C(=O)-CH3. For further information on the types of chemical reactions compounds such as acetyl chloride can undergo, see acyl halide. Two major classes of acetylations include esterification and the Friedel-Crafts reaction.

Acetic acid esters and amide[edit]

Acetyl chloride is a reagent for the preparation of esters and amides of acetic acid, used in the derivatization of alcohols and amines. One class of acetylation reactions are esterification.

CH3COCl + HO-CH2-CH3CH3-COO-CH2-CH3 + HCl

Frequently such acylations are carried out in the presence of a base such as pyridine, triethylamine, or DMAP, which act as catalysts to help promote the reaction and as bases neutralize the resulting HCl. Such reactions will often proceed via ketene.

Friedel-Crafts acetylations[edit]

A second major class of acetylation reactions are the Friedel-Crafts reactions.[7]

See also[edit]

References[edit]

  1. ^ Merck Index, 11th Edition, 79.
  2. ^ Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The Royal Society of Chemistry. 2014. pp. 796–797. doi:10.1039/9781849733069-FP001. ISBN 978-0-85404-182-4.
  3. ^ Cheung, Hosea; Tanke, Robin S.; Torrence, G. Paul (2000). "Acetic Acid". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a01_045.
  4. ^ See:
  5. ^ a b Leo A. Paquette (2005). "Acetyl chloride". Handbook of Reagents for Organic Synthesis, Activating Agents and Protective Groups. John Wiley & Sons. p. 16. ISBN 978-0-471-97927-2.
  6. ^ US 4352761, Erpenbach, Heinz; Gehrmann, Klaus & Lork, Winfried et al., "Production of acetyl chloride", published 1982-10-05, assigned to Hoechst AG 
  7. ^ Charles Merritt, Jr and Charles E. Braun "9-Acetylanthracene" Org. Synth. 1950, 30, 2. doi:10.15227/orgsyn.030.0001

External links[edit]