Acetylornithine deacetylase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
acetylornithine deacetylase
Identifiers
EC number3.5.1.16
CAS number9025-12-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an acetylornithine deacetylase (EC 3.5.1.16) is an enzyme that catalyzes the chemical reaction

N2-acetyl-L-ornithine + H2O acetate + L-ornithine

Thus, the two substrates of this enzyme are N2-acetyl-L-ornithine and H2O, whereas its two products are acetate and L-ornithine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N2-acetyl-L-ornithine amidohydrolase. Other names in common use include acetylornithinase, N-acetylornithinase, and 2-N-acetyl-L-ornithine amidohydrolase. This enzyme participates in urea cycle and metabolism of amino groups.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2F7V and 2F8H.

References[edit]

  • Vogel HJ (1953). "Path of Ornithine Synthesis in Escherichia Coli". Proc. Natl. Acad. Sci. U.S.A. 39 (7): 578–83. doi:10.1073/pnas.39.7.578. PMC 1063827. PMID 16589307.
  • VOGEL HJ, BONNER DM (1956). "Acetylornithinase of Escherichia coli: partial purification and some properties". J. Biol. Chem. 218 (1): 97–106. PMID 13278318.