|Preferred IUPAC name
3D model (JSmol)
|Molar mass||100.12 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Uses for acetylpropionyl include:
- a solvent for cellulose acetate, paints, inks, and lacquers,
- a starting material for dyes, pesticides, and drugs,
- and a flavor, with an odor described as "buttery, cheesy, sweet, nutty, fruity, creamy, caramel".
As a flavoring agent, it is a controversial ingredient in some e-liquid products for use with electronic cigarettes. According to the National Institute for Occupational Safety and Health , inhalation of acetylpropionyl causes respiratory tract epithelial damage and fibrosis to lungs in animal studies. It also causes genetic changes in the animals' brains. Acetylpropionyl was found to cause both intraluminal and intramural fibrotic airway lesions in rats. One study of the composition of 159 different e-liquid products, performed by Farsalinos et al., concluded that the use of acetylpropionyl and diacetyl in E-liquids represents an avoidable risk, and additionally that proper measures should be taken by E-liquid manufacturers and flavoring suppliers to eliminate these hazards from the products.
- Diacetyl, a similar diketone
- Hardo Siegel, Manfred Eggersdorfer "Ketones" in Ullmann's Encyclopedia of Industrial Chemistry, 2005, Wiley-VCH, Weinheim.doi:10.1002/14356007.a15_077
- "CDC - Flavorings-Related Lung Disease: Exposures to Flavoring Chemicals - NIOSH Workplace Safety and Health Topic". www.cdc.gov. Retrieved 2015-10-22.
- Morgan, D. L.; Jokinen, M. P.; Price, H. C.; Gwinn, W. M.; Palmer, S. M.; Flake, G. P. (2012). "Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: Implications for bronchiolitis obliterans in humans". Toxicologic Pathology. 40 (3): 448–65. doi:10.1177/0192623311431946. PMID 22215510.
- Farsalinos, Konstantinos (2014-08-20). "Evaluation of Electronic Cigarette Liquids and Aerosol for the Presence of Selected Inhalation Toxins". Nicotine and Tobacco Research. Oxford Journals. Retrieved 2015-04-06.