Aclidinium bromide

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Not to be confused with Acridinium bromide or Clidinium bromide.
Aclidinium bromide
Aclidinium bromide.svg
Systematic (IUPAC) name
[(8R)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-8-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate bromide
Clinical data
Trade names Bretaris Genuair, Eklira Genuair, Tudorza Pressair
License data
  • US: C (Risk not ruled out)
Routes of
Legal status
Legal status
CAS Number 320345-99-1 N
ATC code R03BB05 (WHO)
PubChem CID 11519741
ChemSpider 9694529 N
KEGG D08837 YesY
Chemical data
Formula C26H30BrNO4S2
Molar mass 564.55 g·mol−1
 NYesY (what is this?)  (verify)

Aclidinium bromide (INN) is a long-acting, inhaled muscarinic antagonist approved in the US on July 24, 2012[1] as a maintenance treatment for chronic obstructive pulmonary disease (COPD).[2]

Evidence shows that it can improve quality of life and prevent hospitalization in those with COPD.[3] However, it does not appear to affect the risk of death or the frequency steroids are needed.[3] It is unclear if it differs from the similar medication tiotropium or another commonly used medication class of LAMAs.[3]

Aclidinium is delivered via a multidose dry powder inhaler, the Genuair inhaler.

Brand names[edit]

It is marketed under the brand name Tudorza Pressair in the US, Eklira Genuair in the UK, and Tudorza Genuair in Canada; licensed to Menarini under the brand name Bretaris Genuair for majority of EU member states[4]


  1. ^ "Forest Laboratories and Almirall Announce FDA Approval of Tudorza™ Pressair™ for the Long-Term Maintenance Treatment of COPD" (Press release). Forest Laboratories. Retrieved 2012-07-24. 
  2. ^ Gavaldà A, Miralpeix M, Ramos I, et al. (2009). "Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile". J Pharmacol Exp Ther. 
  3. ^ a b c Ni, H; Soe, Z; Moe, S (Sep 19, 2014). "Aclidinium bromide for stable chronic obstructive pulmonary disease.". The Cochrane database of systematic reviews 9: CD010509. doi:10.1002/14651858.CD010509.pub2. PMID 25234126. 
  4. ^ "Almirall and Menarini sign a licence agreement and commercial alliance for Aclidinium in the majority of European member states and a number of non-EU countries" (Press release). Menarini. Retrieved 2012-03-26.