Acquired idiopathic generalized anhidrosis

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Acquired idiopathic generalized anhidrosis
Classification and external resources

Acquired idiopathic generalized anhidrosis (AIGA) is characterized by generalized absence of sweating without other autonomic and neurologic dysfunction.[1]

AIGA is classified into 3 subgroups: idiopathic pure sudomotor failure (IPSF), sweat gland failure (SGF), and sudomotor neuropathy, with each subgroup presenting a different pathogenesis.[2][3][4]


Quantitative sudomotor axon reflex test and microneurography are used in the diagnosis of AIGA. However, these refined methods are mostly used for research purposes and not generally available.[5]

Skin biopsy analysis may play a crucial role in the identification of AIGA subgroups.[1]

See also[edit]


  1. ^ a b Chen, Y. C.; Wu, C. S.; Chen, G. S.; Khor, G. T.; Chen, C. H.; Huang, P. (2008). "Identification of Subgroups of Acquired Idiopathic Generalized Anhidrosis". The Neurologist. 14 (5): 318–320. doi:10.1097/NRL.0b013e318173e818. PMID 18784603.
  2. ^ Nakazato, Y.; Tamura, N.; Ohkuma, A.; Yoshimaru, K.; Shimazu, K. (2004). "Idiopathic pure sudomotor failure: Anhidrosis due to deficits in cholinergic transmission". Neurology. 63 (8): 1476–1480. doi:10.1212/01.wnl.0000142036.54112.57. PMID 15505168.
  3. ^ Donadio, V.; Montagna, P.; Nolano, M.; Cortelli, P.; Misciali, C.; Pierangeli, G.; Provitera, V.; Casano, A.; Baruzzi, A.; Liguori, R. (2005). "Generalised anhidrosis: Different lesion sites demonstrated by microneurography and skin biopsy". Journal of Neurology, Neurosurgery & Psychiatry. 76 (4): 588–591. doi:10.1136/jnnp.2004.039263. PMC 1739609. PMID 15774454.
  4. ^ Miyazoe, S.; Matsuo, H.; Ohnishi, A.; Tajima, F.; Fujishita, S.; Ichinose, K.; Shibuya, N. (1998). "Acquired idiopathic generalized anhidrosis with isolated sudomotor neuropathy". Annals of Neurology. 44 (3): 378–381. doi:10.1002/ana.410440314. PMID 9749605.
  5. ^ Hilz, M. J.; Dütsch, M. (2006). "Quantitative studies of autonomic function". Muscle & Nerve. 33 (1): 6–20. doi:10.1002/mus.20365. PMID 15965941.