Acriflavinium chloride

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Acriflavinium chloride
Wireframe of acriflavine
Pure acriflavinium chloride: A brown powder
Pure acriflavinium chloride
IUPAC name
3,6-Diamino-10-methylacridin-10-ium chloride
65589-70-0 N
10597-46-3 (HCl) YesY
ChEBI CHEBI:383703 N
ChemSpider 391386 YesY
21018 (HCl) YesY
EC Number 201-668-8
Jmol 3D model Interactive image
Interactive image
PubChem 443101
15558347 (HCl)
Molar mass 259.74 g·mol−1
R02AA13 (WHO) QG01AC90 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Acriflavine is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. It is a dye and it stains the skin and may irritate. The hydrochloride form is more irritating than the neutral form. It is derived from acridine.

Commercial preparations are often mixtures with proflavine. It is known by a variety of commercial names.

Acriflavine was developed in 1912 by Paul Ehrlich, a German medical researcher, and was used during the First World War against sleeping sickness.[1]

Acriflavine is also used as treatment for external fungal infections of aquarium fish.[2]

Acriflavine has been shown to have anti-cancer activity by inhibition of HIF-1 which prevents blood vessels growing to supply tumors with blood and interferes with glucose uptake and use.[3]

Legal status[edit]

USA, Europe, Canada[edit]


Acriflavine is a controlled substance in Australia and dependent on situation,[clarification needed] is considered either a Schedule 5 (Caution) or Schedule 7 (Dangerous Poison) substance. The use, storage and preparation of the chemical is subject to strict state and territory laws.[citation needed]


  1. ^ acriflavine(Encyclopædia Britannica)
  2. ^ Acriflavine use in aquaria
  3. ^ Lee, K.; Zhang, H.; Qian, D. Z.; Rey, S.; Liu, J. O.; Semenza, G. L. (2009). "Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization". Proceedings of the National Academy of Sciences. 106 (42): 17910. doi:10.1073/pnas.0909353106. 

External links[edit]