||This article needs more medical references for verification or relies too heavily on primary sources. (December 2016)|
Sample of pure acriflavine
Acriflavinium chloride (INN)
3D model (JSmol)
|Molar mass||259.74 g·mol−1|
|R02AA13 (WHO) QG01AC90 (WHO)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Acriflavine (INN: acriflavinium chloride) is a topical antiseptic. It has the form of an orange or brown powder. It may be harmful in the eyes or if inhaled. It is a dye and it stains the skin and may irritate. The hydrochloride form is more irritating than the neutral form. It is derived from acridine. Commercial preparations are often mixtures with proflavine. It is known by a variety of commercial names.
Acriflavine is used in biochemistry for fluorescently labeling high molecular weight RNA.
Acriflavine is a controlled substance in Australia and dependent on situation,[clarification needed] is considered either a Schedule 5 (Caution) or Schedule 7 (Dangerous Poison) substance. The use, storage and preparation of the chemical is subject to strict state and territory laws.
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- acriflavine Encyclopædia Britannica
- Acriflavine use in aquaria
- Lee, K.; Zhang, H.; Qian, D. Z.; Rey, S.; Liu, J. O.; Semenza, G. L. (2009). "Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization". Proceedings of the National Academy of Sciences. 106 (42): 17910. PMC . PMID 19805192. doi:10.1073/pnas.0909353106.
- "Antiseptic used in WWI could hold key to treating superbugs, viral infections, Melbourne researchers say". ABC. November 28, 2016.
- "This forgotten WWI antiseptic could be the key to fighting antibiotic resistance". Science Alert. November 30, 2016.
- "Activation of cGAS-dependent antiviral responses by DNA intercalating agents". Nucleic Acids Research. 45: 198–205. 2016. doi:10.1093/nar/gkw878.