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Combination of
Estradiol Estrogen
Norethisterone acetate Progestogen
Clinical data
AHFS/ Monograph
MedlinePlus a601041
  • US: X (Contraindicated)
Legal status
Legal status
CAS Number 77728-33-7 N
ATC code G03FA01 (WHO)
ChemSpider none
 NYesY (what is this?)  (verify)

Activella (also sold as Estracomb, Kliofem and Novofem) is a combination drug of estradiol and norethisterone acetate used for the treatment of vasomotor symptoms, vulvar and vaginal atrophy and osteoporosis[1] associated with menopause.

Activella supplied as film-coated tablets containing 1 mg estradiol and 0.5 mg norethisterone acetate. Activella is marketed by Novo Nordisk.


  1. ^ Morabito, Nunziata; Crisafulli, Alessandra; Vergara, Caterina; Gaudio, Agostino; Lasco, Antonino; Frisina, Nicola; D'Anna, Rosario; Corrado, Francesco; Pizzoleo, Maria Antonia; Cincotta, Maria; Altavilla, Domenica; Ientile, Riccardo; Squadrito, Francesco (1 October 2002). "Effects of Genistein and Hormone-Replacement Therapy on Bone Loss in Early Postmenopausal Women: A Randomized Double-Blind Placebo-Controlled Study". Journal of Bone and Mineral Research. 17 (10): 1904–1912. doi:10.1359/jbmr.2002.17.10.1904.