Acute myeloblastic leukemia with maturation

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Acute myeloblastic leukemia with maturation
Classification and external resources
Specialty Hematology and oncology
ICD-O M9874/3
MeSH D015470

M2 is a subtype of AML (Acute Myeloid Leukemia).

It is also known as "Acute Myeloblastic Leukemia with Maturation".[1]


This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21).[2] On both sides of the splice the DNA coded for different proteins, RUNX1 and ETO, These two sequences are then transcribed and translated into a single large protein, "M2 AML" which allows the cell to divide unchecked, leading to cancer.


  1. ^ "Acute Myeloid Leukemia - Signs and Symptoms". 
  2. ^ Taj AS, Ross FM, Vickers M et al. (1995). "t(8;21) myelodysplasia, an early presentation of M2 AML". Br. J. Haematol. 89 (4): 890–2. doi:10.1111/j.1365-2141.1995.tb08429.x. PMID 7772527. 

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