Acylfulvene

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Acylfulvene
Acylfulvene.png
Names
IUPAC name
(5'R)-5'-hydroxy-2',5',7'-trimethyl-4'-spiro[cyclopropane-1,6'-indene]one
Identifiers
125392-76-9 N
3D model (Jmol) Interactive image
Interactive image
ChEMBL ChEMBL121987 YesY
ChemSpider 324633 YesY
PubChem 365701
Properties
C14H16O2
Molar mass 216.28 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Acylfulvene is a class of cytotoxic semi-synthetic derivatives of illudin, a natural product that can be extracted from the jack o'lantern mushroom (Omphalotus olearius).[1] One important acylfulvene, 6-hydroxymethylacylfulvene (irofulven), has been evaluated for the treatment of a wide assortment of cancers and tumors.[2] It is thought that acylfulvene compounds kill cancer cells by DNA alkylation (see DNA methylation).[3]

References[edit]

  1. ^ Anchel, M.; Hervey, A.; Robbins, W. J. Proc. Natl. Acad. Sci. U.S.A. 1950, 36, 300
  2. ^ http://clinicaltrials.gov/ct2/results?term=HMAF&Search=Search
  3. ^ Woynarowski, Jan M.; Napier, Cheryl; Koester, Steven K.; Chen, Shih-Fong; Troyer, Dean; Chapman, William; Macdonald, John R. Biochemical Pharmacology (1997), 54 (11), 1181-1193 CODEN: BCPCA6; ISSN 0006-2952. (Elsevier Science Inc.)