She studied at the Architectural Association School of Architecture in London from 1956 to 1959 and at the Technion – Israel Institute of Technology from 1961 to 1962, being awarded her degree in 1963. She has taught extensively in the United States - first at Columbia and then subsequently at Yale and Penn.
In 1986 she and her brother Ram Karmi won an international competition to design the Supreme Court of Israel compound, which opened in 1992. New York Times architecture critic Paul Goldberger wrote of the design, "the sharpness of the Mediterranean architectural tradition and the dignity of the law are here married with remarkable grace."
- In 2007, Karmi-Melamede was awarded the Israel Prize, for architecture. Her father, Dov Karmi, had received the same prize in 1957, and her brother Ram Karmi in 2002.
- Awarded the Sandberg Prize
- "Ram Karmi". Yad LaYeled Children's Museum. Archived from the original on October 7, 2007. Retrieved October 17, 2008.
- Goldberger, Paul (August 13, 1995). "Architecture View: A Public Work That Ennobles As It Serves". New York Times. Retrieved October 20, 2008.
- "Israel Prize Official Site (in Hebrew) - Recipient's C.V.".
- "Israel Prize Official Site (in Hebrew) - Judges' Rationale for Grant to Recipient".
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