Jodorowsky's first guitar lessons were given by The Beatles guitarist George Harrison. In this occasion, Harrison told him that "he was far". Adán did not know if "he was far" in an enlightened way or "far" from being a good guitarist. When he was sixteen he joined the punk band The Hellboys. Then he wanted to try another music genre and meet Yarol Poupaud and Adrienne Pauly, Following these encounters he started playing bass.
On October 30, 2006, he released his first solo album, Étoile Éternelle, as "Adanowsky", and his first single, "L'idole" (meaning "the idol") which was also released in Spanish as "El Ídolo"; the song is about a waiter who wants all the attention and dreams of becoming famous and an idol.
In 2011 he released his third solo album Amador and won the UFI award for "Best International Artist Of The Year" and "Best Live Show". Then he met Devendra Banhart, and together, they recorded the song "You are the one" and "Dime Cuándo". He also helped on Alizée's new album, writing a song for her called "La Cándida".
He won 5 prizes for his movie The Voice Thief as Best director and Best Movie. Also, in 2014, Diane Pernet selected this movie to compete at the ASVOFF festival, the first annual festival in the world about fashion films.
In 2015, Adán Jodorowsky directed a video for his song "Would You Be Mine" with the porn actress Stoya. He is now acting the main character (young Alejandro Jodorowsky) in his father's movie Poesía sin fin, who is the second part of La Danza De La Realidad.