Adenine deaminase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
adenine deaminase
2ics.jpg
adenine deaminase monomer, Enterococcus
Identifiers
EC number3.5.4.2
CAS number9027-68-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an adenine deaminase (EC 3.5.4.2) is an enzyme that catalyzes the chemical reaction

adenine + H2O hypoxanthine + NH3

Thus, the two substrates of this enzyme are adenine and H2O, whereas its two products are hypoxanthine and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is adenine aminohydrolase. Other names in common use include adenase, adenine aminase, and ADase. This enzyme participates in purine metabolism.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2ICS.

References[edit]

  • Blauch M, Koch FC, Hane ME (1939). "A study of xanthine oxidase of rat blood". J. Biol. Chem. 130: 471–486.
  • Heppel LA, Hurwitz J, Horecker BL (1957). "Adenine deaminase of Azotobacter vinelandii". J. Am. Chem. Soc. 79 (3): 630–633. doi:10.1021/ja01560a033.