It was used by the United States military from 1971 to 1999, but was discontinued when the only manufacturer stopped production. This vaccine elicited immunity to serotypes 4 and 7. On March 16, 2011, the U.S. Food and Drug Administration approved an adenovirus vaccine manufactured by Teva Pharmaceuticals under contract to the U.S. Army. This vaccine is essentially the same as the one used from 1971 to 1999. On October 24, 2011 the military services began administering the new adenovirus vaccine to recruits during basic training. In its first year of use, adenovirus vaccine prevented 15,000 cases of Febrile Respiratory Illness, as evidenced by a reduction in the rate of Febrile Respiratory Illness that began soon after October 2011.
- Tucker SN, Tingley DW, Scallan CD (February 2008). "Oral adenoviral-based vaccines: historical perspective and future opportunity". Expert Rev Vaccines. 7 (1): 25–31. doi:10.1586/147605184.108.40.206. PMID 18251691.
- Russell KL, Hawksworth AW, Ryan MA, et al. (April 2006). "Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999-2004". Vaccine. 24 (15): 2835–42. doi:10.1016/j.vaccine.2005.12.062. PMC . PMID 16480793.
- "Vaccine Trials For "Boot Camp Crud" May Help 20 Percent of Recruits". Archived from the original on 12 February 2009. Retrieved 2009-01-15.
- Centers for Disease Control and Prevention (CDC) (July 2001). "Two fatal cases of adenovirus-related illness in previously healthy young adults--Illinois, 2000". MMWR Morb. Mortal. Wkly. Rep. 50 (26): 553–5. PMID 11456329.
- Malarkey MA, Baylor NW. FDA approval letter dated March 16, 2011.
- Croyle MA, Patel A, Tran KN, et al. (2008). Doolan DL, ed. "Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune Response in Mice". PLoS ONE. 3 (10): e3548. doi:10.1371/journal.pone.0003548. PMC . PMID 18958172.
- Hartman ZC, Appledorn DM, Amalfitano A (March 2008). "Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications". Virus Res. 132 (1–2): 1–14. doi:10.1016/j.virusres.2007.10.005. PMID 18036698.
- Tatsis N, Ertl HC (October 2004). "Adenoviruses as vaccine vectors". Mol. Ther. 10 (4): 616–29. doi:10.1016/j.ymthe.2004.07.013. PMID 15451446.