3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||297.33 g·mol−1|
|Melting point||205 °C (401 °F; 478 K)|
|Lethal dose or concentration (LD, LC):|
LD50 (median dose)
|>1000 mg/kg (mouse, oral)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
In 1912, an adenine nucleoside was isolated by Hunter et al. from yeast that were grown without phosphorus or sulfur. Later that substance was shown by Levene and Sobotkal to be adenylthiomethylpentose.
In 1936, W. Nakahara et al. did experiments on rats that suggested that vitamin L2 deficiency inhibits the ability of rats to lactate. In 1942 they identified vitamin L2 to be adenylthiomethylpentose. Later studies by Folley et al refuted Nakahara's claims and demonstrated that L2 is not necessary for lactation and thus L2 is not considered a vitamin today.
Hecht found in 1937 that the body temperature of rabbits, cats and guinea pigs were lowered by 1 to 2 degrees after he gave them adenylthiomethylpentose at a dose of 0.2 g/kg. Kühn et al. replicated this in guinea pigs in 1941.
- Baddiley, J. (1951). "The synthesis of pantothenic acid-2′ and -4′ phosphates as possible degradation products of coenzyme A". Journal of the Chemical Society. 0: 1348–1351. doi:10.1039/JR9510000246.
- JP 04046124, Shimohashi, Hirotaka, issued 1992
- Satoh, Kiyoo; Makino, Katashi (1951). "Structure of Adenylthiomethylpentose". Nature. 167 (4241): 238. Bibcode:1951Natur.167..238S. doi:10.1038/167238a0.
- Michael W. Davidson. "Anthranilic Acid (Vitamin L)".
- J. A. Mandel u. E. K. Dunham (1912). "Preliminary note on a purine-hexose compound". J. Biol. Chem. 11: 85.
- P. A. Levene u. H. Sobotka (1925). "The thio-sugar from yeast" (PDF). J. Biol. Chem. 65: 551.
- Waro Nakahara; Fumito Inukai; Saburo Ugami (1936). "Factor L2, a Second Dietary Factor for Lactation". Proceedings of the Imperial Academy. 12 (9): 289–291. doi:10.2183/pjab1912.12.289.
- Waro Nakahara; Fumito Inukai; Saburo Ugami (1942). "Adenylthiomethylpentose as a Form of Vitamin L2". Proceedings of the Imperial Academy. 18 (8): 477–478. doi:10.2183/pjab1912.18.477.
- S. J. Folley; K. M. Henry; S. K. Kon (1942). "Lactation and Reproduction on Highly Purified Diets". Nature. 150 (3802): 318. Bibcode:1942Natur.150Q.318F. doi:10.1038/150318a0.
- R. Kuhn u. K. Henkel (1941). "Über die Senkung der Körpertemperatur durch Adenylthiomethylpentose". Biological Chemistry. 269 (1): 41–46. doi:10.1515/bchm2.1941.269.1.41.