Adenylyl-sulfate reductase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
adenylyl-sulfate reductase
adenylyl-sulfate reductase heterotetramer, Archaeoglobus fulgidus
EC number1.8.99.2
CAS number9027-75-2
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Adenylyl-sulfate reductase (EC is an enzyme that catalyzes the chemical reaction

AMP + sulfite + acceptor adenylyl sulfate + reduced acceptor

The 3 substrates of this enzyme are AMP, sulfite, and an acceptor, whereas its two products are adenylyl sulfate and a reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with other acceptors. The systematic name of this enzyme class is AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming). Other names in common use include adenosine phosphosulfate reductase, adenosine 5'-phosphosulfate reductase, APS-reductase, APS reductase, AMP, sulfite:(acceptor) oxidoreductase, and (adenosine-5'-phosphosulfate-forming). This enzyme participates in selenoamino acid metabolism and sulfur metabolism. It has 2 cofactors: FAD, and Iron.

Structural studies[edit]

As of late 2014, 6 structures have been solved for this class of enzymes, with PDB accession codes 1JNR, 1JNZ, 2FJA, 2FJB, 2FJD, and 2FJE.


  • Michaels GB, Davidson JT, Peck HD Jr (1970). "A flavin-sulfite adduct as an intermediate in the reaction catalyzed by adenylyl sulfate reductase from Desulfovibrio vulgaris". Biochem. Biophys. Res. Commun. 39 (3): 321–8. doi:10.1016/0006-291X(70)90579-6. PMID 5421934.