Adermatoglyphia Synonyms Immigration delay disease Adermatoglyphia is inherited in an autosomal dominant manner Adermatoglyphia is an extremely rare genetic disorder that causes a person to have no fingerprints. There are only four known extended families worldwide that are affected by this condition.
In 2011, the description of a case of a person from
Switzerland lacking fingerprints as an isolated finding was published. The  phenotype was mapped to chromosome 4q22. In the splice-site of a 3' exon of the gene for SMARCAD1- helicase, a point mutation was detected. It results in a shortened form of the skin-specific protein. The heterozygous mode of mutation suggests an autosomal dominant mode of inheritance.
Other conditions can cause a lack of fingerprints, but unlike them, adermatoglyphia has no other side effects.
Mutations in helicases are involved in other rare genetic diseases, for instance  Werner syndrome.
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