Adhesin molecule (immunoglobulin -like)

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PDB 1gsm EBI.jpg
a reassessment of the madcam-1 structure and its role in integrin recognition.
Symbol Adhes-Ig_like
Pfam PF09085
Pfam clan CL0011
InterPro IPR015169
SCOP 1gsm

In molecular biology, the adhesin molecule (immunoglobulin-like) is a protein domain. This domain is found in mucosal vascular addressin cell adhesion molecule 1 proteins (MAdCAM-1). These are cell adhesion molecules expressed on the endothelium in mucosa that guide the specific homing of lymphocytes into mucosal tissues. MAdCAM-1 belongs to a subclass of the immunoglobulin superfamily (IgSF), the members of which are ligands for integrins.[1] The crystal structure of this domain has been reported; it adopts an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology.[1][2]


  1. ^ a b Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH (June 1998). "The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition". Structure. 6 (6): 793–801. doi:10.1016/S0969-2126(98)00080-X. PMID 9655832. 
  2. ^ Dando J, Wilkinson KW, Ortlepp S, King DJ, Brady RL (February 2002). "A reassessment of the MAdCAM-1 structure and its role in integrin recognition". Acta Crystallogr. D. 58 (Pt 2): 233–41. doi:10.1107/S0907444901020522. PMID 11807247. 

This article incorporates text from the public domain Pfam and InterPro IPR015169