Available structures PDB Ortholog search: PDBe RCSB
List of PDB id codes 4NNT, 1TOU, 1TOW, 2HNX, 2NNQ, 3FR2, 3FR4, 3FR5, 3P6C, 3P6D, 3P6E, 3P6F, 3P6G, 3P6H, 3Q6L, 3RZY, 4NNS, 5EDB, 5EDC, 5D48, 5D4A, 5D45, 5D47 Identifiers Aliases , A-FABP, AFABP, ALBP, HEL-S-104, aP2, fatty acid binding protein 4 FABP4 External IDs OMIM: 600434 MGI: 88038 HomoloGene: 36067 GeneCards: FABP4
Gene location (Mouse) Chr. Chromosome 3 (mouse)  Band 3 A1|3 2.56 cM Start 10,204,088 bp  End 10,208,576 bp  Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 8: 81.48 – 81.48 Mb Chr 3: 10.2 – 10.21 Mb PubMed search   Wikidata
aP2 ( adipocyte Protein 2) is a  carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 ( FABP4). Blocking this protein either through genetic engineering or drugs has the possibility of treating heart disease and the  metabolic syndrome.
See also [ edit ]
References [ edit ]
^ a b c
GRCh38: Ensembl release 89: ENSG00000170323 - Ensembl, May 2017
^ a b c
GRCm38: Ensembl release 89: ENSMUSG00000062515 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL, Boundy KL, Bernlohr DA (1989). "Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA". Biochemistry. 28 (22): 8683–90. doi: 10.1021/bi00448a003. PMID 2481498.
Floresta G, Pistarà V, Amata E, Dichiara M, Marrazzo A, Prezzavento O, Rescifina A (September 2017). "Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review". European Journal of Medicinal Chemistry. 138: 854–873. doi: 10.1016/j.ejmech.2017.07.022. PMID 28738306.
Furuhashi M (March 2019). "Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases". Review. Journal of Atherosclerosis and Thrombosis. 26 (3): 216–232. doi: 10.5551/jat.48710. PMC . 6402888 PMID 30726793.
External links [ edit ]
FABP4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) Human
genome location and FABP4 gene details page in the FABP4 UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Fatty acid-binding protein, adipocyte PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Fatty acid-binding protein, adipocyte