adipocyte protein 2

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FABP4
2HNX.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFABP4, A-FABP, AFABP, ALBP, HEL-S-104, aP2, fatty acid binding protein 4
External IDsOMIM: 600434 MGI: 88038 HomoloGene: 36067 GeneCards: FABP4
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for FABP4
Genomic location for FABP4
Band8q21.13Start81,478,419 bp[1]
End81,483,236 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001442

NM_024406

RefSeq (protein)

NP_001433

NP_077717

Location (UCSC)Chr 8: 81.48 – 81.48 MbChr 3: 10.2 – 10.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

aP2 (adipocyte Protein 2)[5] is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs[6] has the possibility of treating heart disease and the metabolic syndrome.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170323 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062515 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL, Boundy KL, Bernlohr DA (1989). "Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA". Biochemistry. 28 (22): 8683–90. doi:10.1021/bi00448a003. PMID 2481498.
  6. ^ Floresta G, Pistarà V, Amata E, Dichiara M, Marrazzo A, Prezzavento O, Rescifina A (September 2017). "Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review". European Journal of Medicinal Chemistry. 138: 854–873. doi:10.1016/j.ejmech.2017.07.022. PMID 28738306.
  7. ^ Furuhashi M (March 2019). "Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases". Review. Journal of Atherosclerosis and Thrombosis. 26 (3): 216–232. doi:10.5551/jat.48710. PMC 6402888. PMID 30726793.

External links[edit]

  • FABP4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Human FABP4 genome location and FABP4 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Fatty acid-binding protein, adipocyte
  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Fatty acid-binding protein, adipocyte