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The adipokines, or adipocytokines (Greek adipo-, fat; cytos-, cell; and -kinos, movement) are cytokines (cell signaling proteins) secreted by adipose tissue. The first adipokine to be discovered was leptin in 1994.[1] Since that time, hundreds of adipokines have been discovered.[2]

Members include:

In addition, interleukin 8 (IL-8), interleukin 10 (IL-10), interferon gamma (IFN-γ) and inducible protein 10 (IP-10 or CXCL10) have been shown to be associated with excessive body weight.[7]


  1. ^ Conde J, Scotece M, Gómez R, López V, Gómez-Reino JJ, Lago F, Gualillo O (2011). "Adipokines: BioFactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity". BioFactors. 37 (6): 413–420. doi:10.1002/biof.185. PMID 22038756.
  2. ^ Lehr S, Hartwig S, Sell H (2012). "Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders". Proteomics: Clinical Applications. 6 (1–2): 91–101. doi:10.1002/prca.201100052. PMID 22213627.
  3. ^ Guo L, Li Q, Wang W, Yu P, Pan H, Li P, Sun Y, Zhang J. Endocr Res. 2009;34(4):142-54.
  4. ^ MacDougald1, Ormond A. and Burant, Charles F. (September 2007) "The Rapidly Expanding Family of Adipokines" Cell Metabolism 6: pp. 159-161
  5. ^ Monzillo, Lais U. (2003) "Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance" Obesity Research 11(9): pp. 1048-1054
  6. ^ Christiansen T., Richelsen B., and Bruun J.M. (2005) "Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects" International Journal of Obesity 29: pp. 146–150
  7. ^ Sharabiani, MT; Vermeulen R; Scoccianti C; Hosnijeh FS; Minelli L; Sacerdote C; Palli D; Krogh V; Tumino R; Chiodini P; Panico S; Vineis P. (May 2011). "Immunologic profile of excessive body weight". Biomarkers. 16 (3): 243–51. doi:10.3109/1354750X.2010.547948. PMID 21506696.

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