Adipotide, a peptidomimetic with sequence CKGGRAKDC-GG-D(KLAKLAK)2, is an experimental proapoptotic drug that has been shown to cause rapid weight loss in mice and rhesus monkeys. Its mechanism of action is to target specific blood vessels supplying adipose tissue with blood, cause the vessels to shrink and the fat cells fed by those vessels to undergo apoptosis. Adipotide is designed to bind to two receptors, ANXA2 and prohibitin, that are specific to blood vessels supplying white adipose tissue.
- Kolonin, Mikhail G; Saha, Pradip K; Chan, Lawrence; Pasqualini, Renata; Arap, Wadih (2004). "Reversal of obesity by targeted ablation of adipose tissue". Nature Medicine (Nature Publishing Group) 10 (6): 625–632. doi:10.1038/nm1048. PMID 15133506.
- "Blood vessel mapping reveals four new 'ZIP codes'". medicalxpress. 24 October 2011. Retrieved 10 November 2011.
- Barnhart, K. F.; Christianson, D. R.; Hanley, P. W.; Driessen, W. H. P.; Bernacky, B. J.; Baze, W. B.; Wen, S.; Tian, M.; Ma, J.; Kolonin, M. G.; Saha, P. K.; Do, K. A.; Hulvat, J. F.; Gelovani, J. G.; Chan, L.; Arap, W.; Pasqualini, R. (2011). "A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys". Science Translational Medicine 3 (108): 108ra112. doi:10.1126/scitranslmed.3002621. PMID 22072637.