Adraxone; Pink adrenaline
3D model (JSmol)
|Molar mass||179.175 g·mol−1|
|Boiling point||115–120 °C (239–248 °F; 388–393 K) (decomposes)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Adrenochrome is a chemical compound produced by the oxidation of adrenaline (epinephrine). It was the subject of limited research from 1950s through to the 1970s as a potential cause of schizophrenia. While it has no current medical application the related derivative compound, carbazochrome, is a hemostatic medication. Despite this compound's name, it is unrelated to the element chromium, instead the ‑chrome suffix indicates a relationship to color, as pure adrenochrome is deep violet.
The oxidation reaction that converts adrenaline into adrenochrome occurs both in vivo and in vitro. In vitro, silver oxide (Ag2O) is used. In solution, adrenochrome is pink and further oxidation of the compound causes it to polymerize into brown or black melanin compounds.
Several small-scale studies (involving 15 or fewer test subjects) conducted in the 1950s and 1960s reported that adrenochrome triggered psychotic reactions such as thought disorder and derealization.
The treatment of schizophrenia with such potent anti-oxidants is highly contested. In 1973, the American Psychiatric Association reported methodological flaws in Hoffer's work on niacin as a schizophrenia treatment and referred to follow-up studies that did not confirm any benefits of the treatment. Multiple additional studies in the United States, Canada, and Australia similarly failed to find benefits of megavitamin therapy to treat schizophrenia.
In the early 2000s, interest was renewed by the discovery that adrenochrome may be produced normally as an intermediate in the formation of neuromelanin. This finding may be significant because adrenochrome is detoxified at least partially by glutathione-S-transferase. Some studies have found genetic defects in the gene for this enzyme.
In popular culture
- In his 1954 book The Doors of Perception, Aldous Huxley mentioned the discovery and the alleged effects of adrenochrome which he likened to the symptoms of mescaline intoxication, although he had never consumed it.
- Anthony Burgess mentions adrenochrome at the beginning of his 1962 novel A Clockwork Orange. The protagonist and his friends are drinking drug-laced milk: "They had no license for selling liquor, but there was no law yet against prodding some of the new veshches which they used to put into the old moloko, so you could peet it with vellocet or synthemesc or drencrom or one or two other veshches [...]"
- Hunter S. Thompson mentioned adrenochrome in his 1971 book Fear and Loathing in Las Vegas. This is probably the origin of current myths surrounding this compound, because a character states that "There’s only one source for this stuff... the adrenaline glands from a living human body. It’s no good if you get it out of a corpse." The adrenochrome scene also appears in the novel's film adaptation. In the DVD commentary, director Terry Gilliam admits that his and Thompson's portrayal is a fictional exaggeration. Gilliam insists that the drug is entirely fictional and seems unaware of the existence of a substance with the same name. Hunter S. Thompson also mentions adrenochrome in his book Fear and Loathing on the Campaign Trail '72. In the footnotes in chapter April, page 140 he says, "It was sometime after midnight in a ratty hotel room and my memory of the conversation is hazy, due to massive ingestion of booze, fatback, and forty cc's of adrenochrome."
- The harvesting of an adrenal gland from a live victim to obtain adrenochrome for drug abuse is a plot feature in the second episode of the television series Lewis (2007).
- The harvest of adrenochrome from murder victims is a key part of the 2017 horror film Adrenochrome.
- Adrenochrome is a component of several conspiracy theories such as QAnon and the Pizzagate conspiracy theory, with the chemical helping the theories play a similar role to earlier blood libel and satanic ritual abuse stories.
- Heacock, R. A.; Nerenberg, C.; Payza, A. N. (1 May 1958). "The Chemistry of the "Aminochromes": Part I. The Preparation and Paper Chromatography of Pure Adrenochrome". Canadian Journal of Chemistry. 36 (5): 853–857. doi:10.1139/v58-124.
- MacCarthy, Chim, Ind. Paris 55,435(1946)
- A. Hoffer; H. Osmond (22 October 2013). The Hallucinogens. Elsevier. pp. 272–273. ISBN 978-1-4832-6169-0.
- Smythies J (March 2002). "The adrenochrome hypothesis of schizophrenia revisited". Neurotoxicity Research. 4 (2): 147–150. CiteSeerX 10.1.1.688.3796. doi:10.1080/10298420290015827. PMID 12829415. S2CID 37594882.
- Hoffer A, Osmond H, Smithies J (January 1954). "Schizophrenia; a new approach. II. Result of a year's research". The Journal of Mental Science. 100 (418): 29–45. doi:10.1192/bjp.100.418.29. PMID 13152519.
- Hoffer A (1999). "The Adrenochrome Hypothesis and Psychiatry". The Journal of Orthomolecular Medicine. 14 (1): 49–62.
- Hoffer A, Osmond H (1967). The Hallucinogens. Academic Press. ISBN 978-1-4832-6169-0.
- Hoffer A (1994). "Schizophrenia: An Evolutionary Defense Against Severe Stress" (PDF). Journal of Orthomolecular Medicine. 9 (4): 205–2221.
- Lipton MA, Ban TA, Kane FJ, Levine J, Mosher LR, Wittenborn R (1973). "Task Force Report on Megavitamin and Orthomolecular Therapy in Psychiatry" (PDF). American Psychiatric Association. Cite journal requires
- Wittenborn JR, Weber ES, Brown M (1973). "Niacin in the Long-Term Treatment of Schizophrenia". Archives of General Psychiatry. 28 (3): 308–315. doi:10.1001/archpsyc.1973.01750330010002. PMID 4569673.
- Ban TA, Lehmann HE (1970). "Nicotinic Acid in the Treatment of Schizophrenia: A Summary Report". Schizophrenia Bulletin. 1 (3): 5–7. doi:10.1093/schbul/1.3.5.
- Vaughan K, McConaghy N (1999). "Megavitamin and dietary treatment in schizophrenia: a randomised, controlled trial". Australian and New Zealand Journal of Psychiatry. 33 (1): 84–88. doi:10.1046/j.1440-1614.1999.00527.x. PMID 10197889. S2CID 38857700.
- Smythies J (2004). Smythies J (ed.). Disorders of Synaptic Plasticity and Schizophrenia (1st ed.). Elsevier Academic Press. pp. xv. ISBN 978-0-12-366860-8.
- Adams J (7 April 2020). "The truth about adrenochrome". The Spinoff. Retrieved 28 June 2020.
- Friedberg, Brian. "The Dark Virality of a Hollywood Blood-Harvesting Conspiracy". Wired. Retrieved 21 February 2021.
- "Adrenochrome (2017)".
- "Fear and adrenochrome". Spectator USA. 4 May 2020. Retrieved 23 May 2020.
- "How Facebook connects 'pizzagate' conspiracy theorists". NBC News. Retrieved 23 May 2020.
- Dunning, Brian (20 October 2020). "Skeptoid #750: How to Extract Adrenochrome from Children". Skeptoid. Retrieved 20 October 2020.
- Kantrowitz, Lia (29 September 2020). "QAnon, Blood Libel, and the Satanic Panic". The New Republic. Retrieved 8 May 2021.