Adrian V. S. Hill

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Adrian Hill

Born (1958-10-09) 9 October 1958 (age 62)
Alma materTrinity College Dublin
Magdalen College, Oxford
University of Oxford
Known forVaccinology
Spouse(s)
(m. 1994; div. 2020)
Scientific career
FieldsVaccines
InstitutionsJenner Institute
University of Oxford
Vaccitech
ThesisThe distribution and molecular basis of thalassaemia in Oceania (1986)
Doctoral advisorJohn Brian Clegg, David Weatherall
Websitehttps://www.ox.ac.uk/news-and-events/find-an-expert/professor-adrian-hill

Adrian Vivian Sinton Hill, KBE FRS FMedSci FRCP (born 9 October 1958)[1] is an Irish vaccinologist, Director of the Jenner Institute and Lakshmi Mittal and Family Professor of Vaccinology at the University of Oxford, an honorary Consultant Physician in Infectious Diseases,[2] and Fellow of Magdalen College, Oxford.[3] Hill is a leader in the field of malaria vaccine development and was a co-leader of the research team which produced the Oxford–AstraZeneca COVID-19 vaccine, along with Professor Sarah Gilbert of the Jenner Institute and Professor Andrew Pollard of the Oxford Vaccine Group.[4]

Early life and education[edit]

Hill was educated at Belvedere College in Dublin.[1] He began reading medicine at Trinity College Dublin, where he was elected a Foundation Scholar in 1978.[5] Thereupon he transferred to Magdalen College, Oxford for one year, but he ended up remaining in Oxford to complete the rest of his medical degree, qualifying in 1982.[6][3] He remained at the University of Oxford for postgraduate studies and was awarded a Doctor of Philosophy degree in 1986[7] for research on the molecular genetics of thalassemia supervised by John B. Clegg [Wikidata].[3][8]

Career and research[edit]

During his time at the Wellcome Trust Centre for Human Genetics his research group studied genetic susceptibility to infections such as malaria, tuberculosis, and HIV. From 1997 [9] he has developed candidate vaccines for malaria which produce cellular (T-cell) immunity and partial efficacy using Adenovirus and Modified vaccinia Ankara (MVA) viral vector vaccines in a prime-boost regime.[10] From 2005 he has played a leading role in the pre-clinical and clinical assessment of new chimpanzee adenoviral vaccine vectors, particularly ChAd63, ChAd3 and ChAdOx1. His group has developed numerous candidate vaccines against malaria which have been tested in clinical trials in the UK and Africa.[11] In 2021 his group reported high efficacy of a new R21/matrix-M candidate vaccine in Burkina Faso children and this vaccine is now in a phase III licensure trial.[12] In 2014, he led a clinical trial of an Ebola vaccine based on chimpanzee adenoviral and MVA vector technology in response to the West African Ebola virus epidemic.[10][13][14] In 2016 he co-founded Vaccitech plc, an Oxford University spin-off company developing therapeutic and preventive vaccines based on viral vector technology.[15] In 2017 he led a successful major award application to Innovate UK to co-found the Vaccines Manufacturing and Innovation Centre (VMIC) in Harwell, Oxfordshire, one of the first purpose-built vaccine manufacturing centres for emergency response vaccines.[16] In response to the 2020 COVID-19 pandemic he worked with many others at Oxford to develop and partner the ChAdOx1 vector-based SARS-CoV-2 vaccine, notably with AstraZeneca and the Serum Institute of India, supporting large scale access for low and middle income countries.[17]

Honours and awards[edit]

Personal life[edit]

Hill has two children with his former wife, the epidemiologist Sunetra Gupta.[1]

References[edit]

  1. ^ a b c d e "Hill, Prof. Adrian Vivian Sinton". Who's Who. ukwhoswho.com. A & C Black, an imprint of Bloomsbury Publishing plc. 2020. doi:10.1093/ww/9780199540884.013.U59812. (subscription or UK public library membership required)
  2. ^ "Adrian Hill". www.ndm.ox.ac.uk. Retrieved 20 July 2021.
  3. ^ a b c d https://www.magd.ox.ac.uk/member-of-staff/adrian-hill/%7Ctitle=Professor Adrian Hill, Fellow by Special Election}}
  4. ^ "Oxford University academics recognised in Queen's Birthday Honours | University of Oxford". www.ox.ac.uk. Retrieved 20 July 2021.
  5. ^ "List of scholars - Scholars - TCD". www.tcdlife.ie. Retrieved 20 July 2021.
  6. ^ a b "Fellows and Scholars 2008". Trinity College Dublin. Retrieved 23 August 2020.
  7. ^ Hill, Adrian Vivian Sinton (1986). The distribution and molecular basis of thalassaemia in Oceania. bodleian.ox.ac.uk (DPhil thesis). University of Oxford. OCLC 59703987. EThOS uk.bl.ethos.375250.
  8. ^ "Professor Adrian Hill". oxfordmartin.ox.ac.uk. Oxford Martin School. Retrieved 25 January 2016.
  9. ^ "Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara".
  10. ^ a b "Professor Adrian VS Hill - Nuffield Department of Medicine". ndm.ox.ac.uk. Retrieved 25 January 2016.
  11. ^ "Adrian Hill: Malaria Vaccines - Nuffield Department of Medicine". ndm.ox.ac.uk. Retrieved 25 January 2016.
  12. ^ "Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial". May 2021.
  13. ^ University of Oxford (11 March 2016), Oxford London Lecture 2016: Vaccines for Ebola: Tackling a Market Failure, retrieved 17 February 2018
  14. ^ Oxford Martin School (26 November 2015), Prevent and protect: vaccines and immune responses, retrieved 17 February 2018
  15. ^ "Our Team - Vaccitech". vaccitech.co.uk. Retrieved 17 February 2018.
  16. ^ "Dramatic increase in the UK vaccine capability". 3 December 2018.
  17. ^ "Meet the Irish scientist behind Oxford's coronavirus vaccine". IrishCentral.com. 21 July 2020. Retrieved 11 October 2020.
  18. ^ a b "Accelerating vaccine development". royalsociety.org. Retrieved 17 February 2018.
  19. ^ "Adrian Hill". theconversation.com. The Conversation. Retrieved 17 February 2018.
  20. ^ "Future of Oxford professorship in vaccinology secured with £3.5 million gift University of Oxford".
  21. ^ "Oxford Researchers elected to Royal Society | University of Oxford". www.ox.ac.uk. Retrieved 8 May 2021.
  22. ^ "Honorary Awards to Foreign Nationals in 2021". Gov.UK. 2021.