From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
IUPAC name
(3S)-3-[3-(3-Hydroxy-4-methoxyphenyl)propylamino]-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
Systematic IUPAC name
N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-α-L-aspartyl]-L-phenylalanine 1-methyl ester
3D model (JSmol)
E number E969 (glazing agents, ...)
Molar mass 458.51 g·mol−1
Appearance white to yellow powder
Melting point 99.3–101.5 °C (210.7–214.7 °F; 372.4–374.6 K)
Slightly soluble
Safety data sheet External MSDS
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Advantame is a non-caloric sweetener from Japan's Ajinomoto Co.[1] The U.S. Food and Drug Administration has approved advantame for general use in foods and beverages except meat and poultry as a food additive. It is synthesized from isovanillin and aspartame.[2] The E number for advantame is E969.

Advantame is classified as generally recognized as safe (GRAS) by the Flavor and Extract Manufacturers Association for use in dairy, frozen desserts, beverages, and chewing gum (FEMA #: 4716).[3] The Center for Science in the Public Interest ranks advantame as safe, together with neotame from other artificial intensity sweeteners.[4]

Animal studies have found no evidence for carcinogenicity or developmental toxicity.[5]

It is marketed as 20,000 times sweeter than sugar,[6] but it is not commonly used.[7]


  1. ^ "FDA Approves New No-Calorie Sweetener". Medscape. May 21, 2014. Retrieved 22 May 2014.
  2. ^
  3. ^ "Ajinomoto - Advantame Home". Advantame.
  4. ^ "Comparison and Safety Ratings of Food Additives". Center for Science in the Public Interest.
  5. ^ Otabe, A.; Fujieda, T.; Masuyama, T.; Ubukata, K.; Lee, C. (November 2011). "Advantame – An overview of the toxicity data". Food and Chemical Toxicology. 49: S2–S7. doi:10.1016/j.fct.2011.06.046.
  6. ^ "Food Additives & Ingredients - Additional Information about High-Intensity Sweeteners Permitted for Use in Food in the United States". Retrieved 14 January 2018.
  7. ^ "Nonnutritive Sweeteners: Current Use and Health Perspectives". Circulation. Retrieved 14 January 2018.

External links[edit]