Affective spectrum

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The affective spectrum is a spectrum of affective disorders (mood disorders).[1] It is a grouping of related psychiatric and medical disorders which may accompany bipolar, unipolar, and schizoaffective disorders at statistically higher rates than would normally be expected. These disorders are identified by a common positive response to the same types of pharmacologic treatments. They also aggregate strongly in families and may therefore share common heritable underlying physiologic anomalies.


Affective spectrum disorders include:

The following may also be present as co-morbidities for affective mood disorders

Also, there are now studies linking heart disease.[5]

Many of the terms above overlap. The American Psychiatric Association's definitions of these terms can be found in the Diagnostic and Statistical Manual of Mental Disorders (DSM).

See also[edit]


  1. ^ Renato D. Alarcon; William G. Walter-Ryan; Patricia A. Rippetoe (1987). "Affective spectrum disorders". Comprehensive Psychiatry. 28 (4): 292–308. doi:10.1016/0010-440X(87)90065-4. PMID 3608463.
  2. ^ a b c d e f g h Hudson JI, Pope HG Jr (1990). "Affective spectrum disorder: does antidepressant response identify a family of disorders with a common pathophysiology?". Am J Psychiatry. 147 (5): 552–64. doi:10.1176/ajp.147.5.552. PMID 2183630.
  3. ^ a b c d e f g h i j k l m n Hudson JI, Mangweth B, Pope HG Jr, De Col C, Hausmann A, Gutweniger S, Laird NM, Biebl W, Tsuang MT (1990). "Family study of affective spectrum disorder". Arch Gen Psychiatry. 60 (2): 170–7. doi:10.1001/archpsyc.60.2.170. PMID 12578434.
  4. ^ McElroy SL, Soutullo CA, Beckman DA, Taylor P Jr, Keck PE Jr (1998). "DSM-IV intermittent explosive disorder: a report of 27 cases". J Clin Psychiatry. 59 (4): 203–10. doi:10.4088/jcp.v59n0411. PMID 9590677.
  5. ^ Fenton WS, Stover ES (2006). "Mood disorders: cardiovascular and diabetes comorbidity". Curr Opin Psychiatry. 19 (4): 421–7. doi:10.1097/01.yco.0000228765.33356.9f. PMID 16721175.