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An aglycone (aglycon[1] or genin) is the compound remaining after the glycosyl group on a glycoside is replaced by a hydrogen atom.[2] For example, the aglycone of a cardiac glycoside would be a steroid molecule.


A way to identify aglycone is proposed to extract it from Agave spp. by using H-NMR and Heteronuclear multiple bond correlation (HMBC) experiments. The HMBC experiment can be combined with other techniques such as mass spectrometry to further examine the structure and the function of aglycone.[3]

A study on molecular markers in human aortic endothelial cells published that aglycone stoped cell migration but not monocyte adhesion, which is the initial step of atherosclerotic plaque formation.[4]

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  1. ^ "2-Carb-33". Archived from the original on 12 November 2016. Retrieved 21 April 2018.
  2. ^ IUPAC Compendium of Chemical Terminology 2nd Edition (1997) 1995, 67, 1312
  3. ^ Simonet, Ana, Features in the NMR spectra of the aglycones of Agave spp. saponins. HMBC method for aglycone identification (HMAI), 32, pp. 38–61, PMID 32515107
  4. ^ Giménez‐Bastida, Juan A., Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF‐α‐induced inflammation and associated molecular markers in human aortic endothelial cells, 56, pp. 784–796

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