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Lake Agnano formed in the Middle Ages, and this was drained in 1870 to increase arable land and reduce the habitat of the Anopheles mosquito, which carries the malaria parasite. The crater is now home to the Agnano hippodrome and a few hotels.
After World War II, Agnano crater (valley) was home to the U.S. Naval Support Activity, Naples, Italy. This base consisted of the U.S. Naval Hospital, Naples, administrative offices, barracks, and a commissary/exchange.
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