The song gained national fame after being re-recorded by white recording artist Pat Boone. Domino's version soon became more popular, bringing Domino's music to the mass market a half dozen years after his first major recording, "The Fat Man".
After "Ain't That a Shame", mainstream artists began covering Domino's songs. Teresa Brewer, for instance, performed the Domino rewrite of a folk song called "Bo Weevil".
According to legend, Pat Boone suggested the title and lyrics be altered to "Isn't That A Shame" to make it more appealing to a broader audience but was dissuaded by his producers. Despite his suggestion being rejected, Boone had his first Billboardnumber-one single in 1955. Domino complimented Boone's cover of the song. Boone likes to tell the story about a Fats Domino concert and Domino invited Boone on stage. Domino showed a big gold ring and said "Pat Boone bought me this ring."