Aipysurus duboisii, also known as the Dubois' sea snake or reef shallows sea snake, is a species of venomous sea snake. Its geographic range includes Papua New Guinea, New Caledonia and the northern, eastern and western coastal areas of Australia, that is the Coral Sea, Arafura Sea, Timor Sea and Indian Ocean. They live at depths up to 80 meters (262 feet) in coral reef flats, sandy and silty sediments which contain seaweed, invertebrates and corals or sponges that can serve as shelter. These snakes feed on moray eels and various fish that live on the seafloor, up to 110 cm (3.6 feet) in size. They are viviparous, giving birth to live young rather than laying eggs. They have medium aggressiveness, i.e., will bite if provoked, but not spontaneously. The fangs are 1.8 mm long, which are relatively short for a snake, and the venom yield is 0.43 mg. Aipysurus duboisii is a crepuscular species, meaning that they are most active at dawn and dusk.
Adults of A. duboisii grow up to 148 cm (4.86 feet) in total length (including tail) but usually to around 80 cm (2.6 feet). The head is slightly wider than the neck with nostrils on its upper part and nasals contacting each other. Eyes are separated from supralabial scales by a row of large subocular scales. Dorsal scales are usually smooth, but sometimes have a small keel or small knobs. Individuals vary significantly in color and its body patterns. The tail is relatively long; the chin and throat have lighter color than rest of the body.
The acute toxicity of snake venom is conventionally tested on laboratory animals and is evaluated in terms of the median lethal dose (LD50), that is, the dose required to kill half the members of a tested population divided by the weight of the tested animal. The LD50 depends on the animal. Rabbits are about twice as sensitive to sea snake venom as mice, and fish and frogs are even more susceptible. The LD50 for subcutaneous injection of A. duboisii venom into mice is 0.044 mg/kg of body weight. This makes A. duboisii the most venomous sea snake tested, and one of the top three most venomous snakes in the world, together with the inland taipan (Oxyuranus microlepidotus, LD50=0.025 mg/kg) and the eastern brown snake (Pseudonaja textilis, LD50=0.0365 mg/kg).
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