|Classification and external resources|
Akathisia, or acathisia (from Greek καθίζειν kathízein - "to sit", a- indicating negation or absence, lit. "inability to sit") is a syndrome characterized by unpleasant sensations of inner restlessness that manifests itself with an inability to sit still or remain motionless. The term was coined by the Czech neuropsychiatrist Ladislav Haskovec (1866–1944), who described the phenomenon in 1901.
Antipsychotics (also known as neuroleptics) may cause akathisia. Other known causes include side effects of certain medications, and nearly any physically-addictive drug during drug withdrawal. It is also associated with Parkinson's disease and related syndromes.
Akathisia may range in intensity from a sense of disquiet or anxiety, to severe discomfort, particularly in the knees. Patients typically pace for hours because the pressure on the knees reduces the discomfort somewhat; once their knees and legs become fatigued and they are unable to continue pacing, they sit or lie down, although this does not relieve the akathisia. At high doses or with potent drugs such as haloperidol (Haldol) or chlorpromazine (Thorazine/Largactil), the feeling can last all day from awakening to sleep. The anticholinergic medication procyclidine reduces neuroleptic-induced akathisia to a certain degree, in addition to preventing and sometimes eliminating the muscle stiffness that can occur alongside akathisia. When misdiagnosis occurs in antipsychotic neuroleptic-induced akathisia, more antipsychotic neuroleptics may be prescribed, potentially worsening the symptoms. High-functioning patients have described the feeling as a sense of inner tension and torment or chemical torture. Many patients describe symptoms of neuropathic pain akin to fibromyalgia and Restless Legs Syndrome. In Han et al. (2013), the authors describe Restless Legs Syndrome's relation to akathisia, "Some researchers regard RLS as a 'focal akathisia' [in the legs]." Although these side effects disappear quickly and remarkably when the medication is stopped, tardive, or late-persisting akathisia may go on long after the offending drug is discontinued, sometimes for a period of years—unlike the related tardive dyskinesia, which can be permanent.
Healy, et al. (2006), described the following regarding akathisia: tension, insomnia, a sense of discomfort, motor restlessness, and marked anxiety and panic. Increased labile affect can result, such as weepiness. Interestingly, in some people the opposite response to SSRIs occurs, in the form of emotional blunting; but sufficient clinical research has not yet been made in this area.
...[It comes] from so deep inside you, you cannot locate the source of the pain … The muscles of your jawbone go berserk, so that you bite the inside of your mouth and your jaw locks and the pain throbs. … Your spinal column stiffens so that you can hardly move your head or your neck and sometimes your back bends like a bow and you cannot stand up. … You ache with restlessness, so you feel you have to walk, to pace. And then as soon as you start pacing, the opposite occurs to you; you must sit and rest. Back and forth, up and down you go … you cannot get relief …
In a psychiatric setting, patients who suffer from neuroleptic-induced akathisia often react by refusing treatment.
Published epidemiological data for akathisia is mostly limited to treatment periods preceding the arrival of second-generation antipsychotics (SGAs). Sachdev (1995) reported an incidence rate of acute akathisia of 31% for 100 patients treated for 2 weeks with antipsychotic medications. Sachdev (1995) reported a prevalence range from 0.1% to 41%. In all likelihood, rates of prevalence are lower for current treatment as second generation antipsychotics carry a lower risk of akathisia.
The presence and severity of akathisia can be measured using the Barnes Akathisia Scale, which assesses both objective and subjective criteria. Precise assessment of akathisia is problematic as it is difficult to differentiate from a multitude of disorders with similar symptoms. In a study of movement disorders induced by neuroleptics, akathisia was found in only 26% of patients originally diagnosed with akathisia. The primary distinguishing features of akathisia in comparison with other syndromes are primarily subjective characteristics, such as the feeling of inner restlessness. Akathisia can commonly be mistaken for agitation secondary to psychotic symptoms or mood disorder, antipsychotic dysphoria, Restless Legs Syndrome, anxiety, insomnia, drug withdrawal states, tardive dyskinesia, or other neurological and medical conditions.
Additionally, there is the controversial diagnosis of "pseudoakathisia", as noted by Mark J. Garcia. In his article discussing akathisia among adults with severe and profound intellectual disability, he describes pseudoakathisia as "comprising all the symptoms of abnormal movements seen with akathisia, but without a sense of restlessness".
Han et al. (2013) reported that upon examination of three patients who experienced abrupt onset of restlessness characteristic of akathisia and Restless Legs Syndrome (RLS), magnetic resonance imaging of the brain revealed pontine infarction (lack of blood to the Pons area of the brain). Han et al. wrote, "The features of our three patients suggest that RLS and akathisia may have a common pathophysiological mechanism related to the pontine region of the brain."
Akathisia is frequently associated with the use of antipsychotic drugs that are dopamine receptor antagonists. There is still limited understanding on the pathophysiology of akathisia, but it is seen to be associated with medications which block dopaminergic transmission in the brain. Additionally, drugs with successful therapeutic effects in the treatment of medication-induced akathisia have provided additional insight into the involvement of other transmitter systems. These include benzodiazepines, ß-adrenergic blockers, and serotonin antagonists. Another major cause of the syndrome is the withdrawal of various addictive drugs in dependent individuals.
It has been correlated with Parkinson's disease and related syndromes. It is unclear, however, whether this is due more to Parkinson's or the drugs used to treat it, such as carbidopa/levodopa (levocarb).
Antidepressants can also induce the appearance of akathisia. The 2006 UK study by Healy et al. observed that akathisia is often miscoded in antidepressant clinical trials as "agitation, emotional lability, and hyperkinesis (overactivity)". The study further points out that misdiagnosis of akathisia as simple motor restlessness occurs, but that this is more properly classed as dyskinesia. Moreover, it shows links between antidepressant-induced akathisia and violence, including suicide, since akathisia can "exacerbate psychopathology", going on to state that there is extensive clinical evidence correlating akathisia with SSRI use—approximately ten times as many patients on SSRIs compared to placebo (5.0% versus 0.5%) showed symptoms severe enough to drop out of a trial.
It was discovered that akathisia involves increased levels of the neurotransmitter norepinephrine, which is associated with mechanisms that regulate aggression, alertness, and arousal. Though no further research has been done yet, it may also be involved with disrupted NMDA channels in the brain, which have both synergistic and regulatory effects on norepinephrine.
The table below summarizes factors that can induce akathisia, grouped by type, with examples or brief explanations for each:
|Antipsychotics||Haloperidol (Haldol), droperidol, pimozide, trifluoperazine, amisulpride, risperidone, aripiprazole (Abilify), lurasidone (Latuda), ziprasidone and asenapine (Saphris)|
|SSRIs||Fluoxetine (Prozac), paroxetine (Paxil), citalopram (Celexa)|
|Antidepressants||Venlafaxine (Effexor), tricyclics, and trazodone (Desyrel)|
|Anti-emetics||Metoclopramide (Reglan), prochlorperazine (Compazine), and promethazine|
|Antihistamines||Cyproheptadine (Periactin) or diphenhydramine (Benadryl) — this is more commonly seen at very high doses|
|Drug withdrawal||Opioid withdrawal, barbiturates withdrawal, cocaine withdrawal|
|Serotonin Syndrome||Harmful combinations of psychotropic drugs|
Akathisia is completely reversible and typically subsides once the causative agent has been identified and discontinued. Case reports and small randomized studies suggest that benzodiazepines, propranolol, and anticholinergics may help treat acute akathisia somewhat, but are much less effective in treating chronic akathisia. Taylor et al. found success in lowering the dose of antipsychotic medication as an initial response to drug-induced akathisia, which should be done gradually, if possible. To minimize the risk of akathisia from antipsychotics, the clinician is advised to be conservative when increasing dosages.
If the patient is experiencing akathisia due to opioid withdrawal, a moderate dose of any opioid (e.g., morphine, fentanyl, methadone, oxycodone) will relieve it all together. GABA analogues pregabalin and gabapentin may also be effective is certain cases (an extended release form of gabapentin, gabapentin enacarbil, is approved to treat the related condition Restless Legs Syndrome) .
Additional pharmacologic interventions found to have anti-akathisia effects (especially for neuroleptic-induced akathisia) include ß-adrenergic antagonists (e.g., propranolol), benzodiazepines (e.g., lorazepam), anticholinergics (e.g., benztropine) as well as serotonin antagonists (e.g., cyproheptadine) as an alternative.
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