Akinetic mutism is a medical term describing patients tending neither to move (akinesia) nor speak (mutism). Akinetic mutism was first described in 1941 by Cairns et al. as a mental state where patients lack the ability to move or speak. However, their eyes may follow their observer or be diverted by sound. Patients lack most motor functions such as speech, facial expressions, and gestures, but demonstrate apparent alertness. They exhibit reduced activity and slowness, and can speak in whispered monosyllables. Patients often show visual fixation on their examiner, move their eyes in response to an auditory stimulus, or move after often repeated commands. Patients with akinetic mutism are not paralyzed, but lack the will to move. Many patients describe that as soon as they ‘will’ or attempt a movement, a ‘counter-will’ or ‘resistance’ rises up to meet them.
- 1 Description
- 2 Symptoms
- 3 Causes
- 4 Diagnosis and treatment
- 5 History
- 6 See also
- 7 References
Akinetic mutism varies across all patients. Its form, intensity, and clinical features correspond more closely to its functional anatomy rather than to its pathology. However, akinetic mutism most often appears in two different forms: frontal and mesencephalic.
Frontal akinetic mutism
Akinetic mutism can occur in the frontal region of the brain and occurs because of bilateral frontal lobe damage. Akinetic mutism as a result of frontal lobe damage is clinically characterized as hyperpathic. It occurs in patients with bilateral circulatory disturbances in the supply area of the anterior cerebral artery.
Mesencephalic akinetic mutism
Akinetic mutism can also occur as a result of damage to the mesencephalic region of the brain. Mesencephalic akinetic mutism is clinically categorized as somnolent or apathetic akinetic mutism. It is characterized by vertical gaze palsy and ophthalmoplegia. This state of akinetic mutism varies in intensity, but it is distinguished by drowsiness, lack of motivation, hyper-somnolence, and reduction in spontaneous verbal and motor actions.
- Lack of motor function (but not paralysis)
- Lack of speech 
Akinetic mutism can be caused by a variety of things. It often occurs after brain injury or as a symptom of other diseases.
Frontal lobe damage
Akinetic mutism is often the result of severe frontal lobe injury in which the pattern of inhibitory control is one of increasing passivity and gradually decreasing speech and motion.
Ablation of cingulate gyrus
Another cause of both akinesia and mutism is ablation of the cingulate gyrus. Destruction of the cingulate gyrus has been used in the treatment of psychosis. Such lesions result in akinesia, mutism, apathy, and indifference to painful stimuli. The anterior cingulate cortex is thought to supply a "global energizing factor" that stimulates decision making. When the anterior cingulate cortex is damaged, it can result in akinetic mutism.
Akinetic mutism is a symptom during the final stages of Creutzfeldt-Jakob Disease (a rare degenerative brain disease) and can help diagnose patients with this disease. It can also occur in a stroke that affects both anterior cerebral artery territories. Another cause is neurotoxicity due to exposure to certain drugs such as tacrolimus and cyclosporine.
Other causes of akinetic mutism are as follows:
- Respiratory arrest and cerebral hypoxia 
- Acute cases of encephalitis lethargica
- Aneurysms 
- Olfactory groove meningioma
- Cyst in third ventricle 
- Toxical lesions and infections of central nervous system 
- Delayed post-hypoxic leukoencephalopathy (DPHL) 
- Creutzfeldt-Jakob Disease (mesencephalic form) 
Diagnosis and treatment
Akinetic mutism can be misdiagnosed as depression, delirium, or locked-in syndrome, all of which are common following a stroke. Patients with depression can experience apathy, slurring of speech, and body movements similar to akinetic mutism. Similarly to akinetic mutism, patients with locked-in syndrome experience paralysis and can only communicate with their eyes. Correct diagnosis is important to ensure proper treatment. A variety of treatments for akinetic mutism have been documented, but treatments vary between patients and cases.
Treatments using intravenous magnesium sulfate have shown to reduce the symptoms of akinetic mutism. In one case, a 59 year old woman was administered intravenous magnesium sulfate in an attempt to resolve her akinetic mutism. The patient was given 500 mg of magnesium every eight hours, and improvement was seen after 24 hours. She became more verbal and attentive, and treatment was increased to 1000 mg every eight hours as conditions continued to improve.
As seen in the case of Elsie Nicks, the puncture or removal of a cyst causing akinetic mutism can relieve symptoms almost immediately. However, if the cyst fills up again, the symptoms can reappear.
Dopamine agonist therapy
Symptoms of akinetic mutism suggest a possible presynaptic deficit in the nigrostriatal pathway, which transmits dopamine. Some patients with akinetic mutism have shown to improve with levodopa or dopamine agonist therapy, or by repleting dopamine in the motivational circuit with stimulants, antidepressants, or agonists such as bromocriptine or amantadine.
Fourteen-year-old Elsie Nicks was the first patient to be diagnosed with akinetic mutism by Cairns in 1941. She suffered from severe headaches her entire life and was eventually given morphia to help with treatment. She began to enter a state of akinetic mutism, experiencing apathy and loss of speech and motor control. A cyst on her right lateral ventricle was tapped, and as soon as the needle advanced toward the cyst, she let out a loud noise and was able to state her name, age, and address. After her cyst was emptied, she regained her alertness and intelligence, and she had no recollection of her time spent in the hospital. The cyst was drained two more times over the next seven months and was eventually removed. After eight months of rehabilitation, Elsie no longer experienced headaches or akinetic mutism symptoms.
- Cairns, H; R. C. Oldfield; J.B. Pennybacker; D. Whitteridge (1941). "AKINETIC MUTISM WITH AN EPIDERMOID CYST OF THE 3RD VENTRICLE.". Brain 64 (4): 273–290. doi:10.1093/brain/64.4.273.
- Otto, Anke; Inga Zerr; Maria Lantsch (1998). "Akinetic mutism as a classification criterion for the diagnosis of Creutzfeldt-Jakob Disease". Journal of Neurology, Neurosurgery, and Psychiatry 64: 524–528. doi:10.1136/jnnp.64.4.524. PMC 2170038. PMID 9576547.
- Nagaratnam, Nages; Kujan Nagaratnam; Kevin Ng; Patrick Diu (2004). "Akinetic mutism following stroke". Journal of Clinical Neuroscience 11 (1): 25–30. doi:10.1016/j.jocn.2003.04.002. PMID 14642361.
- Sacks, Oliver (1973). Awakenings. United States: Vintage Books. p. 7.
- Nagaratnam, Nages; Catriona McNeil; J.S. Gilhotra (1999). "Akinetic mutism and mixed transcortical aphasia following left thalamo-mesencephalic infarction". Journal of the Neurological Sciences 163 (1): 70–73. doi:10.1016/s0022-510x(98)00329-3. PMID 10223414.
- Yarns, Brandon; Davin Quinn (2013). "Telephone Effect in Akinetic Mutism From Traumatic Brain Injury". Psychosomatics 54 (6): 1–2. doi:10.1016/j.psym.2013.06.006. PMID 23932533.
- Fix JD. Neuroanatomy. 4th ed.
- Struss, DT; Alexander MP; Shallice T; Picton TW; Binns MA; Macdonald R; Borowiec A; Katz DI. (2005). "Multiple frontal systems controlling response speed". Neuropsychologia 43 (3): 396–417. doi:10.1016/j.neuropsychologia.2004.06.010. PMID 15707616.
- Vachalová, Ivana; Viola Gindl; Josef G. Heckmann (August 2013). "Acute inferior homonymous quandrantanopia in a 71-year-old woman". Journal of Clinical Neuroscience 21: 683–685. doi:10.1016/j.jocn.2013.05.015. PMID 24210803.
- Kotchoubey, Boris; Manfred Schneck; Simone Lang; Niels Birbaumer (2003). "Event-related brain potentials in a patient with akinetic mutism". Clinical Neurophysiology 33 (1): 23–30. doi:10.1016/S0987-7053(03)00003-0. PMID 12711129.
- Rozen, Todd (2012). "Rapid resolution of akinetic mutism in delayed post-hypoxic leukoencephalopathy with intravenous magnesium sulfate". Neurorehabilitation 30 (4): 329–332. doi:10.3233/nre-2012-0763. PMID 22672948.
- Yang, Chun-Pai; Huang, Shih, Lin, Lu, Kao, Hsieh, Huang, Lee, Tsai (2007). "Diminution of basal ganglia dopaminergic function may play an important role in the generation of akinetic mutism in a patient with anterior cerebral arterial infarct". Clinical Neurology and Neurosurgery 109 (7): 602–606. doi:10.1016/j.clineuro.2007.04.012. PMID 17543443.