Alan Fersht

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Sir Alan Fersht
Alan Fersht.jpg
Alan Roy Fersht

(1943-04-21) 21 April 1943 (age 75)[1]
Hackney, London
NationalityUnited Kingdom
Alma materUniversity of Cambridge
Known forProtein folding
Marilyn Persell (m. 1966)
Scientific career
ThesisIntramolecular catalysis of ester hydrolysis (1968)
Doctoral students

Sir Alan Roy Fersht, FRS, FMedSci[4] (born 21 April 1943) is a British chemist at the Laboratory of Molecular Biology and an Emeritus Professor in the Department of Chemistry at the University of Cambridge.[8] He works on protein folding.[9][10][11][12][13][14][15][16] Former Master of Gonville and Caius College, Cambridge.[17][18][19][20][21][22][23]

Early life[edit]

Fersht was born on 21 April 1943.[1] He was educated at Sir George Monoux Grammar School, an all-boys grammar school in Walthamstow, London.[1] He went on to study at Gonville and Caius College, Cambridge, where he was awarded his PhD degree in 1968.[24]

Career and research[edit]

Fersht was Wolfson Research Professor of the Royal Society and Professor of Biological Chemistry at Imperial College London from 1978 to 1988 and was Herchel Smith Professor of Organic Chemistry at Cambridge from 1988 to 2010. He was the Director of the Cambridge Centre for Protein Engineering from 1990 to 2010. He is a Fellow of both Gonville & Caius College and Imperial College.[12]

Alan Fersht is widely regarded as one of the main pioneers of protein engineering, which he developed as a primary method for analysis of the structure, activity and folding of proteins. He has developed methods for the resolution of protein folding in the sub-millisecond time-scale and has pioneered the method of phi value analysis for studying the folding transition states of proteins. His interests also include protein misfolding, disease and cancer.[5]

Awards and honours[edit]

Fersht's name on Staircase L at Gonville & Caius College, Cambridge in 2010.
Scientists sharing L1 in Caius Court, Gonville and Caius College, Cambridge, taken in 1994 (Nevill Mott, Samuel Frederick Edwards, David Tabor, David Shoenberg, Rodney Hill and Alan Fersht.

Fersht was elected a Fellow of the Royal Society (FRS) in 1983.[3] The Royal Society awarded him the Gabor Medal in 1991 for molecular biology, in 1998 the Davy Medal for chemistry and in 2008 the Royal Medal. He is a Foreign Associate of the United States National Academy of Sciences,[2] a Foreign Member of the American Philosophical Society, a Foreign Member of the Accademia dei Lincei, an Honorary Foreign Member of the American Academy of Arts and Sciences and a Fellow of the Academy of Medical Sciences.[4] His nomination for the Royal Society reads:

Fersht holds honorary doctorates from: Uppsala University(1999);[25] Free University of Brussels; Weizmann Institute of Science; Hebrew University of Jerusalem; and University of Aarhus.

Fersht has received many prizes and medals including: the FEBS Anniversary Prize; Novo Biotechnology Award; Charmian Medal of the Royal Society of Chemistry; Max Tishler Lecture and Prize Harvard University; The Datta Lectureship and Medal of the Federation of European Biochemical Societies; Jubilee Lecture and the Harden Medal of the Biochemical Society; Feldberg Foundation Prize, Distinguished Service Award, Miami Nature Biotechnology Winter Symposium; Christian B. Anfinsen Award of the Protein Society; Natural Products Award of the Royal Society of Chemistry, Stein and Moore Award of the Protein Society;[26][27] Bader Award of the American Chemical Society; Kaj Ulrik Linderstrøm-Lang Prize and Medal; Bijvoet Medal of the Bijvoet Center for Biomolecular Research of Utrecht University in 2008 and the Gilbert N. Lewis Medal University of California, Berkeley, and the Wilhelm Exner Medal in 2009.[28]

In 2003 he was knighted for his pioneering work on protein science.[1] His citation on elected to the Academy of Medical Sciences reads:

Personal life[edit]

Fersht's recreations include chess[29] and horology.[1] He married Marilyn Persell in 1966 and has one son and one daughter.[1]

Selected publications[edit]

  • Fersht, Alan. Structure and mechanism in protein science : a guide to enzyme catalysis and protein folding. New Jersey. ISBN 9789813225190. OCLC 986523773.
  • Fersht, Alan; Wang, Qinghua (2010). The selected papers of Sir Alan Fersht : development of protein engineering. London: Imperial College Press. ISBN 9781848165540. OCLC 646400491.


  1. ^ a b c d e f g FERSHT, Sir Alan (Roy). Who's Who. 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. closed access (subscription required)
  2. ^ a b "Alan Fersht, University of Cambridge, Election Year: 1993". National Academy of Sciences. Archived from the original on 17 April 2015.
  3. ^ a b c "EC/1983/09: Fersht, Alan Roy". London: The Royal Society. Archived from the original on 13 May 2014.
  4. ^ a b c d "Professor Sir Alan Fersht FRS FMedSci". Academy of Medical Sciences. Archived from the original on 17 April 2015.
  5. ^ a b Alan Fersht publications indexed by Google Scholar
  6. ^ "Women at Cambridge: Jane Clarke". University of Cambridge. Archived from the original on 24 March 2015.
  7. ^ Clarke, J; Fersht, A. R. (1993). "Engineered disulfide bonds as probes of the folding pathway of barnase: Increasing the stability of proteins against the rate of denaturation". Biochemistry. 32 (16): 4322–9. doi:10.1021/bi00067a022. PMID 8476861.
  8. ^ "Professor Sir Alan Fersht FRS, Department of Chemistry, University of Cambridge". Retrieved 26 July 2011.
  9. ^ Jackson, S. E.; Fersht, A. R. (1991). "Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition". Biochemistry. 30 (43): 10428–10435. doi:10.1021/bi00107a010. PMID 1931967.
  10. ^ Fersht, A. R.; Shi, J. P.; Knill-Jones, J.; Lowe, D. M.; Wilkinson, A. J.; Blow, D. M.; Brick, P.; Carter, P.; Waye, M. M. Y.; Winter, G. (1985). "Hydrogen bonding and biological specificity analysed by protein engineering". Nature. 314 (6008): 235–238. doi:10.1038/314235a0. PMID 3845322.
  11. ^ Matouschek, A.; Kellis, J. T.; Serrano, L.; Fersht, A. R. (1989). "Mapping the transition state and pathway of protein folding by protein engineering". Nature. 340 (6229): 122–126. doi:10.1038/340122a0. PMID 2739734.
  12. ^ a b Fersht, A.; Matouschek, A.; Serrano, L. (1992). "The folding of an enzyme I. Theory of protein engineering analysis of stability and pathway of protein folding". Journal of Molecular Biology. 224 (3): 771–782. doi:10.1016/0022-2836(92)90561-W. PMID 1569556.
  13. ^ Fersht, Alan (1999). Structure and mechanism in protein science: a guide to enzyme catalysis and protein folding. San Francisco: W.H. Freeman. ISBN 0-7167-3268-8.
  14. ^ Wilkinson, A. J. (2010). "The Selected Papers of Sir Alan Fersht: Development of Protein Engineering". Protein Engineering Design and Selection. 24: 225–227. doi:10.1093/protein/gzq103.
  15. ^ Qinghua Wang; Fersht, Alan (2010). Selected Papers of Sir Alan Fersht: The Development of Protein Engineering (Icp Selected Papers). River Edge, N.J: Imperial College Press. ISBN 1-84816-554-4.
  16. ^ Fersht, Alan (1985). Enzyme structure and mechanism. San Francisco: W.H. Freeman. ISBN 0-7167-1614-3.
  17. ^ "Professor Sir Alan Fersht FRS becomes the 42nd Master of Caius". Archived from the original on 22 April 2015. Retrieved 21 November 2012.
  18. ^ Europabio: profile[dead link]
  19. ^ BBC: brief Fersht career summary at time of knighthood
  20. ^ "Imperial College London: biographical summary Alan Fersht". Archived from the original on 27 June 2009.
  21. ^ "Fersht webpage at MRC Laboratory of Molecular Biology, Cambridge UK". Archived from the original on 14 September 2014.
  22. ^ Alan Fersht's publications indexed by the Scopus bibliographic database. (subscription required)
  23. ^ Fersht, A. R. (2013). "Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 nobel laureates in chemistry". Proceedings of the National Academy of Sciences of the United States of America. 110 (49): 19656–7. doi:10.1073/pnas.1320569110. PMC 3856823. PMID 24277833.
  24. ^ Fersht, Alan Roy (1968). Intramolecular catalysis of ester hydrolysis (PhD thesis). University of Cambridge.(subscription required)
  25. ^
  26. ^ "Alan R. Fersht receives Bader Award / Corey Award to David W. C. Mac Millan / Breslow Award to Peter B. Dervan". Angewandte Chemie International Edition. 43 (41): 5430. 2004. doi:10.1002/anie.200462026. PMID 15484254.
  27. ^ "Alan Fersht. 2001 Stein and Moore Award". Protein Science. 10 (4): 905. 2001. PMID 11345067.
  28. ^ editor, ÖGV. (2015). Wilhelm Exner Medal. Austrian Trade Association. ÖGV. Austria.
  29. ^ Fersht, Alan (2007). Jaques Staunton Chess Sets 1849–1939. Kaissa Publications. ISBN 0-9557325-0-6.
Academic offices
Preceded by
Sir Christopher Hum
Master of Gonville and Caius College, Cambridge
Succeeded by
Pippa Rogerson