Albumin I

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Albumin_I
PDB 1p8b EBI.jpg
Solution structure of PA1b. PDB entry 1p8b[1]
Identifiers
Symbol Albumin_I
Pfam PF08027
Pfam clan CL0083
InterPro IPR012512

Albumin I (PA1b) is a hormone-like peptide found in the seeds of legumes such as the pea plant (pisum sativum)[2] or soya bean (Glycine max)[3] which have been shown to have insecticidal properties.[2] It stimulates kinase activity upon binding a membrane bound 43 kDa receptor within the plant which affects cell proliferation.[3] The structure reveals an inhibitor cystine knot (knottin)-like fold, comprising three beta strands.[1][2]

References[edit]

  1. ^ a b Jouvensal, L.; Quillien, L.; Ferrasson, E.; Rahbé, Y.; Guéguen, J.; Vovelle, F. O. (2003). "PA1b, an Insecticidal Protein Extracted from Pea Seeds (Pisum sativum): 1H-2-D NMR Study and Molecular Modeling†,‡". Biochemistry 42 (41): 11915–11923. doi:10.1021/bi034803l. PMID 14556622.  edit
  2. ^ a b c Da Silva, P.; Rahioui, I.; Laugier, C.; Jouvensal, L.; Meudal, H.; Chouabe, C.; Delmas, A. F.; Gressent, F. (2010). "Molecular Requirements for the Insecticidal Activity of the Plant Peptide Pea Albumin 1 Subunit b (PA1b)". Journal of Biological Chemistry 285 (43): 32689–32694. doi:10.1074/jbc.M110.147199. PMC 2963353. PMID 20660598.  edit
  3. ^ a b Yamazaki T, Takaoka M, Katoh E, Hanada K, Sakita M, Sakata K, Nishiuchi Y, Hirano H (March 2003). "A possible physiological function and the tertiary structure of a 4-kDa peptide in legumes". Eur. J. Biochem. 270 (6): 1269–76. doi:10.1046/j.1432-1033.2003.03489.x. PMID 12631285. 

This article incorporates text from the public domain Pfam and InterPro IPR012512